Title:
COMPOSITIONS AND METHODS FOR REDUCING BIOFILM FORMATION
Document Type and Number:
WIPO Patent Application WO/2023/240237
Kind Code:
A3
Abstract:
Compositions and methods for reducing or eliminating biofilm formation are disclosed. The compositions include an O-glycan substituted silk fibroin with a predetermined degree and distribution of O-glycan substitution. The O-glycan substituted silk fibroin is not cytotoxic to the population of biofilm-forming microbes, but it reduces or prevents biofilm formation, nonetheless.
Inventors:
WERLANG CAROLINE (US)
RIBBECK KATHARINA (US)
KIESSLING LAURA (US)
SAHOO JUGAL (US)
KAPLAN DAVID (US)
RIBBECK KATHARINA (US)
KIESSLING LAURA (US)
SAHOO JUGAL (US)
KAPLAN DAVID (US)
Application Number:
PCT/US2023/068204
Publication Date:
March 14, 2024
Filing Date:
June 09, 2023
Export Citation:
Assignee:
TUFTS COLLEGE (US)
MASSACHUSETTS INST TECHNOLOGY (US)
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
A61L27/54; A61K9/08; A61L27/36; C09D7/63
Foreign References:
| US20090162439A1 | 2009-06-25 |
Other References:
FEI XIANG, JIA MINGHUI, DU XIN, YANG YUHONG, ZHANG REN, SHAO ZHENGZHONG, ZHAO XIA, CHEN XIN: "Green Synthesis of Silk Fibroin-Silver Nanoparticle Composites with Effective Antibacterial and Biofilm-Disrupting Properties", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 14, no. 12, 9 December 2013 (2013-12-09), US , pages 4483 - 4488, XP093149604, ISSN: 1525-7797, DOI: 10.1021/bm4014149
MOH EDWARD S. X., PACKER NICOLLE H.: "Enzymatic Azido-GalNAc-Functionalized Silk Fibroin for Click Chemistry Conjugation", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 22, no. 4, 12 April 2021 (2021-04-12), US , pages 1752 - 1755, XP093149607, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.0c01791
MOH EDWARD S. X., PACKER NICOLLE H.: "Enzymatic Azido-GalNAc-Functionalized Silk Fibroin for Click Chemistry Conjugation", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 22, no. 4, 12 April 2021 (2021-04-12), US , pages 1752 - 1755, XP093149607, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.0c01791
Attorney, Agent or Firm:
IRIZARRY, Stacey et al. (US)
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