Title:
COMPOSITIONS AND METHODS FOR THE REDUCTION OR PREVENTION OF HEPATIC STEATOSIS AND NASH
Document Type and Number:
WIPO Patent Application WO/2019/161211
Kind Code:
A3
Abstract:
Methods useful for reducing or preventing hepatic steatosis and NASH are provided herein. Such methods may comprise administering to a subject in need thereof an FXR agonist in combination with an amount of a branched amino acid in free amino acid form, such as leucine, or a metabolite thereof. Also provided herein are compositions and kits for practicing any of the methods described herein.
Inventors:
ZEMEL MICHAEL (US)
BRUCKBAUER ANTJE (US)
BANERJEE JHEELAM (US)
BRUCKBAUER ANTJE (US)
BANERJEE JHEELAM (US)
Application Number:
PCT/US2019/018230
Publication Date:
April 30, 2020
Filing Date:
February 15, 2019
Export Citation:
Assignee:
NUSIRT SCIENCES INC (US)
International Classes:
A61K47/06; A61K31/13; A61K47/28; C07J5/00; C07J9/00; C07J51/00
Foreign References:
| US20050158408A1 | 2005-07-21 | |||
| US20160213639A1 | 2016-07-28 |
Attorney, Agent or Firm:
SUSANTO, Christina (US)
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