Title:
COMPOSITIONS AND METHODS REGARDING DIRECT NADH UTILIZATION TO PRODUCE 3-HYDROXYPROPIONIC ACID, DERIVED CHEMICALS AND FURTHER DERIVED PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2013/043758
Kind Code:
A3
Abstract:
The present invention regards microbial production of malonate semialdehyde, 3-hydroxypropionate, and products derived thereof, including using a combinations of malonyl CoA reductase domains and 3-HP dehydrogenase domains with altered cofactor specificities for NADH and NADPH. Embodiments of the present invention also include methods for engineering these proteins, the genetically engineered microorganisms used for production with these altered enzymes, methods for producing such organisms, and methods of making compounds, downstream compounds, and downstream, products.
Inventors:
MERCOGLIANO CHRISTOPHER P (US)
WATSON FAITH DIZON (US)
LIPSCOMB TANYA E W (US)
LIAO HANS H (US)
LYNCH MICHAEL D (US)
WATSON FAITH DIZON (US)
LIPSCOMB TANYA E W (US)
LIAO HANS H (US)
LYNCH MICHAEL D (US)
Application Number:
PCT/US2012/056159
Publication Date:
June 13, 2013
Filing Date:
September 19, 2012
Export Citation:
Assignee:
OPX BIOTECHNOLOGIES INC (US)
MERCOGLIANO CHRISTOPHER P (US)
WATSON FAITH DIZON (US)
LIPSCOMB TANYA E W (US)
LIAO HANS H (US)
LYNCH MICHAEL D (US)
MERCOGLIANO CHRISTOPHER P (US)
WATSON FAITH DIZON (US)
LIPSCOMB TANYA E W (US)
LIAO HANS H (US)
LYNCH MICHAEL D (US)
International Classes:
C12N15/74; C12P7/42
Foreign References:
| US20110125118A1 | 2011-05-26 | |||
| US7638316B2 | 2009-12-29 | |||
| US20120244588A1 | 2012-09-27 |
Attorney, Agent or Firm:
WILLIS, Michael et al. (650 Page Mill RoadPal Alto, CA, US)
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