COMPOSITIONS AND METHODS RELATING TO MACROPHAGES AND/OR MONOCYTES WITH ADHERED PARTICLES

Title:

COMPOSITIONS AND METHODS RELATING TO MACROPHAGES AND/OR MONOCYTES WITH ADHERED PARTICLES

Document Type and Number:

WIPO Patent Application WO/2019/139892

Kind Code:

A1

Abstract:

Provided herein are polymeric particles and compositions (i.e., "backpacks") that can adhere to cells and provide delivery of payload immunomodulatory agents to those cells. For examples, the particles can adhere to macrophages and/or monocytes and release cytokines that promote an M1 or M2 phenotype to improve therapeutic efficacy of the cells.

Inventors:

SHIELDS IV CHARLES WYATT (US)
MITRAGOTRI SAMIR (US)
EVANS MICHAEL ANDREW (US)

Application Number:

PCT/US2019/012673

Publication Date:

July 18, 2019

Filing Date:

January 08, 2019

Export Citation:

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Assignee:

HARVARD COLLEGE (US)
UNIV CALIFORNIA (US)
SHIELDS IV CHARLES WYATT (US)

International Classes:

A61K45/06; A61K35/15

Foreign References:

US20150010630A1	2015-01-08
US20090258057A1	2009-10-15

Other References: