Title:
COMPOSITIONS AND METHODS FOR SELECTIVE DISSOLUTION OF NASCENT INTRAVASCULAR BLOOD CLOTS
Document Type and Number:
WIPO Patent Application WO2005004804
Kind Code:
A3
Abstract:
Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots, which are capable of selective dissolution of pathological nascent clots formed intravascularly, with minimal risk of unwanted dissolution of pre-existing hemostatic clots, are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.
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Inventors:
MUZYKANTOV VLADIMIR R (US)
MURCIANO JUAN CARLOS (ES)
CINES DOUGLAS (US)
MURCIANO JUAN CARLOS (ES)
CINES DOUGLAS (US)
Application Number:
PCT/US2004/020660
Publication Date:
May 12, 2005
Filing Date:
June 28, 2004
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
MUZYKANTOV VLADIMIR R (US)
MURCIANO JUAN CARLOS (ES)
CINES DOUGLAS (US)
MUZYKANTOV VLADIMIR R (US)
MURCIANO JUAN CARLOS (ES)
CINES DOUGLAS (US)
International Classes:
A61K9/00; A61K35/18; A61K38/16; A61K38/17; A61K38/49; C12N5/08; C12N9/70; C12N9/72; C12N9/96; A61K; (IPC1-7): A61K38/49; C12N9/70; C12N9/72; C12N9/96
Other References:
MUZYKANTOV ET AL.: "Regulation of the complement-mediated elimination of red blood cells modified with biotin and streptavidin", ANAL. BIOCHEM., vol. 241, 1996, XP001013314
KAJIHARA ET AL.: "Physicochemical characterization of PRG-PPG conjugated human urokinase", BIOCHEMICA ET BIOPHYSICA ACTA, vol. 1199, 1994, pages 202 - 208, XP002985052
KAJIHARA ET AL.: "Physicochemical characterization of PRG-PPG conjugated human urokinase", BIOCHEMICA ET BIOPHYSICA ACTA, vol. 1199, 1994, pages 202 - 208, XP002985052
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