Title:
COMPOSITIONS AND METHODS FOR SILENCING DNAJC15 GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2021/202443
Kind Code:
A3
Abstract:
The disclosure relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the DNAJC15 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of DNAJC15.
Inventors:
TREMBLAY FREDERIC (US)
MCININCH JAMES (US)
MCININCH JAMES (US)
Application Number:
PCT/US2021/024769
Publication Date:
March 03, 2022
Filing Date:
March 30, 2021
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS INC (US)
International Classes:
C12N15/113; A61K31/713
Domestic Patent References:
| WO2005116204A1 | 2005-12-08 | |||
| WO2012018881A2 | 2012-02-09 |
Foreign References:
| US20190078086A1 | 2019-03-14 | |||
| US20110178283A1 | 2011-07-21 |
Other References:
NICOL?S NAVASA ET AL: "Regulation of Oxidative Stress by Methylation-Controlled J Protein Controls Macrophage Responses to Inflammatory Insults", JOURNAL OF INFECTIOUS DISEASES, vol. 211, no. 1, 14 July 2014 (2014-07-14), US, pages 135 - 145, XP055313237, ISSN: 0022-1899, DOI: 10.1093/infdis/jiu389
Attorney, Agent or Firm:
MEIGS, Julie Broadus et al. (US)
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