Title:
COMPOSITIONS AND METHODS FOR TARGETED CYTOKINE DELIVERY
Document Type and Number:
WIPO Patent Application WO/2017/136818
Kind Code:
A3
Abstract:
The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to an NKG2D ligand or PD1 ligand and may improve immunotherapy by limiting side effects associated with immunotherapy. The present disclosure also encompasses compositions and methods for recruiting cytotoxic lymphocytes to target cells using NKG2D receptor ligands or PD1 ligands. The compositions disclosed herein comprise a NKG2D receptor ligand and a targeting molecule and may improve immunotherapy by limiting side effects associated with immunotherapy.
Inventors:
KRUPNICK ALEXANDER SASHA (US)
LAZEAR ERIC REED (US)
WESTWICK JOHN (US)
FREMONT DAVED HENRY (US)
LAZEAR ERIC REED (US)
WESTWICK JOHN (US)
FREMONT DAVED HENRY (US)
Application Number:
PCT/US2017/016688
Publication Date:
June 07, 2018
Filing Date:
February 06, 2017
Export Citation:
Assignee:
UNIV WASHINGTON (US)
International Classes:
C07K19/00
Domestic Patent References:
| WO2016100375A2 | 2016-06-23 |
Foreign References:
| US20110150870A1 | 2011-06-23 | |||
| US20050249706A1 | 2005-11-10 | |||
| US20110311517A1 | 2011-12-22 |
Other References:
KANG, TH ET AL.: "Tumor-Targeted Delivery of IL -2 by NKG2D Leads to Accumulation of Antigen-Specific CD 8+ T Cells in the Tumor Loci and Enhanced Anti-Tumor Effects", PLOS ONE, vol. 7, no. 4, 11 April 2012 (2012-04-11), pages 1 - 9, XP055511017
SAUVE, K ET AL.: "Localization in Human Interleukin 2 of the Binding Site to the Alpha chain (p55) of the Interleukin 2 Receptor", PROCEEDINGS TO THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 88, no. 11, 1 June 1991 (1991-06-01), pages 4636 - 4640, XP002317471
STRAUSBERG, RL ET AL.: "Generation and Initial Analysis of More Than 15,000 Full-Length Human and Mouse cDNA Sequences", PROCEEDINGS TO THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 99, no. 26, 7 October 2002 (2002-10-07), pages 16899 - 16903, XP055158136
WU, X ET AL.: "Myosin-Reactive Autoantibodies in Rheumatic Carditis and Normal Fetus", CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 87, no. 2, May 1998 (1998-05-01), pages 184 - 192, XP029574126
SAUVE, K ET AL.: "Localization in Human Interleukin 2 of the Binding Site to the Alpha chain (p55) of the Interleukin 2 Receptor", PROCEEDINGS TO THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 88, no. 11, 1 June 1991 (1991-06-01), pages 4636 - 4640, XP002317471
STRAUSBERG, RL ET AL.: "Generation and Initial Analysis of More Than 15,000 Full-Length Human and Mouse cDNA Sequences", PROCEEDINGS TO THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 99, no. 26, 7 October 2002 (2002-10-07), pages 16899 - 16903, XP055158136
WU, X ET AL.: "Myosin-Reactive Autoantibodies in Rheumatic Carditis and Normal Fetus", CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 87, no. 2, May 1998 (1998-05-01), pages 184 - 192, XP029574126
Attorney, Agent or Firm:
RILEY-VARGAS, Rebecca et al. (US)
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