Title:
COMPOSITIONS AND METHODS TO DETECT KIDNEY FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2019/217899
Kind Code:
A3
Abstract:
Disclosed are compositions and methods to detect proteins associated with kidney fibrosis. Such biomarkers may be useful to allow individuals susceptible to kidney fibrosis to manage their lifestyle and reduce further progression of disease.
More Like This:
Inventors:
JESSEN WALTER JOSEPH (US)
ENNIS JENNIFER LYNN (US)
ASPLIN JOHN ROBERT (US)
ENNIS JENNIFER LYNN (US)
ASPLIN JOHN ROBERT (US)
Application Number:
PCT/US2019/031835
Publication Date:
December 26, 2019
Filing Date:
May 10, 2019
Export Citation:
Assignee:
LABORATORY CORP AMERICA HOLDINGS (US)
International Classes:
G01N33/68
Foreign References:
| US20030119010A1 | 2003-06-26 |
Other References:
CHEN X. ET AL.: "Urinary TGF-1 has a supplementary value in predicting renal function recovery post unilateral ureteral obstruction", INT. UROL. NEPHROL., vol. 47, no. 1, 9 October 2014 (2014-10-09), pages 33 - 37, XP035418516
VEGA G. ET AL.: "The cellular and signalling alterations conducted by TGF-beta contributing to renal fibrosis", CYTOKINE, vol. 88, 4 September 2016 (2016-09-04), pages 115 - 125, XP029767694
MANSOUR S.G. ET AL.: "Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review", BMC NEPHROLOGY, vol. 18, no. 1, 72, 20 February 2017 (2017-02-20), pages 1 - 13, XP055636976
CHENG S. ET AL.: "Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation", AM. J. PATHOL., vol. 162, no. 6, June 2003 (2003-06-01), pages 1937 - 1949, XP055606656
GENOVESE F. ET AL.: "The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?", FIBROGENESIS & TISSUE REPAIR, vol. 7, no. 1, 4, 28 March 2014 (2014-03-28), pages 1 - 14, XP021183690
PERCO P. ET AL.: "Protein biomarkers associated with acute renal failure and chronic kidney disease", EUR. J. CLIN. INVEST., vol. 36, no. 11, November 2006 (2006-11-01), pages 753 - 763, XP002495251
RAMPOLDI L. ET AL.: "The rediscovery of uromodulin (Tamm-Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease", KIDNEY INT., vol. 80, no. 4, August 2011 (2011-08-01), pages 338 - 347, XP055271503
PHANISH M.K. ET AL.: "The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGF beta 1 responses in human proximal-tubule epithelial cells", BIOCHEM. J., vol. 393, no. 2, 15 January 2006 (2006-01-15), pages 601 - 607, XP055098220
ZHANG Y. ET AL.: "Role of Smad signaling in kidney disease", INT. UROL. NEPHROL., vol. 47, no. 12, 3 October 2015 (2015-10-03), pages 1965 - 1975, XP035934125
LI J.H. ET AL.: "Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking smad2 activation", J. AM. SOC. NEPHROL., vol. 13, no. 6, 2002, pages 1464 - 1472, XP002980369
VEGA G. ET AL.: "The cellular and signalling alterations conducted by TGF-beta contributing to renal fibrosis", CYTOKINE, vol. 88, 4 September 2016 (2016-09-04), pages 115 - 125, XP029767694
MANSOUR S.G. ET AL.: "Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review", BMC NEPHROLOGY, vol. 18, no. 1, 72, 20 February 2017 (2017-02-20), pages 1 - 13, XP055636976
CHENG S. ET AL.: "Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation", AM. J. PATHOL., vol. 162, no. 6, June 2003 (2003-06-01), pages 1937 - 1949, XP055606656
GENOVESE F. ET AL.: "The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?", FIBROGENESIS & TISSUE REPAIR, vol. 7, no. 1, 4, 28 March 2014 (2014-03-28), pages 1 - 14, XP021183690
PERCO P. ET AL.: "Protein biomarkers associated with acute renal failure and chronic kidney disease", EUR. J. CLIN. INVEST., vol. 36, no. 11, November 2006 (2006-11-01), pages 753 - 763, XP002495251
RAMPOLDI L. ET AL.: "The rediscovery of uromodulin (Tamm-Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease", KIDNEY INT., vol. 80, no. 4, August 2011 (2011-08-01), pages 338 - 347, XP055271503
PHANISH M.K. ET AL.: "The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGF beta 1 responses in human proximal-tubule epithelial cells", BIOCHEM. J., vol. 393, no. 2, 15 January 2006 (2006-01-15), pages 601 - 607, XP055098220
ZHANG Y. ET AL.: "Role of Smad signaling in kidney disease", INT. UROL. NEPHROL., vol. 47, no. 12, 3 October 2015 (2015-10-03), pages 1965 - 1975, XP035934125
LI J.H. ET AL.: "Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking smad2 activation", J. AM. SOC. NEPHROL., vol. 13, no. 6, 2002, pages 1464 - 1472, XP002980369
Attorney, Agent or Firm:
ROTHSCHILD, Cynthia B. et al. (US)
Download PDF:
Previous Patent: CCL21 AND CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER
Next Patent: PROXIMITY INDUCED SITE-SPECIFIC ANTIBODY CONJUGATION
Next Patent: PROXIMITY INDUCED SITE-SPECIFIC ANTIBODY CONJUGATION