COMPOSITIONS AND METHODS TO ENHANCE VIABILITY AND FUNCTION OF ISLET CELLS

Title:

COMPOSITIONS AND METHODS TO ENHANCE VIABILITY AND FUNCTION OF ISLET CELLS

Document Type and Number:

WIPO Patent Application WO2007081654

Kind Code:

B1

Abstract:

This invention uses placental alkaline phosphatase ("PALP"), and other members of the alkaline phosphatase family, to reduce the death and thereby maintain or enhance the viability and function of insulin-producing islet ß-cells including insulin secretion. PALP may be administered to a patient that has received transplanted islet cells to protect the transplanted islets against ROS-mediated attacks by the patient's immune system. Transferrin and other promoters of islet survival may also be used to enhance the effects of PALP on islet viability both in vivo and in vitro.

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Inventors:

KISS ZOLTAN (US)

Application Number:

PCT/US2006/062458

Publication Date:

July 17, 2008

Filing Date:

December 21, 2006

Export Citation:

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Assignee:

ZOLTAN LAB LLC (US)
KISS ZOLTAN (US)

International Classes:

A61K38/46

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