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Title:
COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS
Document Type and Number:
WIPO Patent Application WO/2016/082789
Kind Code:
A1
Abstract:
Described herein are neuroactive steroids of the Formula (II) : or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and ----- are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e. g., such for inducing sedation and/or anesthesia.

Inventors:
BOTELLA GABRIEL MARTINEZ (US)
HARRISON BOYD L (US)
ROBICHAUD ALBERT JEAN (US)
SALITURO FRANCESCO G (US)
BERESIS RICHARD THOMAS (CN)
Application Number:
CN2015/095765
Publication Date:
June 02, 2016
Filing Date:
November 27, 2015
Export Citation:
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Assignee:
SAGE THERAPEUTICS INC (US)
BOTELLA GABRIEL MARTINEZ (US)
HARRISON BOYD L (US)
ROBICHAUD ALBERT JEAN (US)
SALITURO FRANCESCO G (US)
BERESIS RICHARD THOMAS (CN)
International Classes:
C07J3/00; A61K31/56; A61P25/00; A61P25/08; C07J17/00; C07J43/00
Domestic Patent References:
WO2014169831A12014-10-23
WO1995021617A11995-08-17
WO2014169832A12014-10-23
WO2006037016A22006-04-06
WO2014071449A12014-05-15
Foreign References:
Other References:
See also references of EP 3224269A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (Building 110 Caihefang Road, Haidian District, Beijing 0, CN)
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