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Title:
COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS
Document Type and Number:
WIPO Patent Application WO/2016/082789
Kind Code:
A1
Abstract:
Described herein are neuroactive steroids of the Formula (II) : or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and ----- are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e. g., such for inducing sedation and/or anesthesia.

Inventors:
BOTELLA, Gabriel Martinez (17 Parmenter Road, Wayland, Massachusetts, 01778, US)
HARRISON, Boyd L. (9 Wheatston Court, Princeton Junction, New Jersey, 08550, US)
ROBICHAUD, Albert Jean (2 Earhart St, 915Cambridge, Massachusetts, 02141, US)
SALITURO, Francesco G. (25 Baker Drive, Marlborough, Massachusetts, 01752, US)
BERESIS, Richard Thomas (Apartment 2504, Building 1 199 Shimen,#2 Road, Shanghai 0, 200040, CN)
Application Number:
CN2015/095765
Publication Date:
June 02, 2016
Filing Date:
November 27, 2015
Export Citation:
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Assignee:
SAGE THERAPEUTICS, INC. (215 First Street, Cambridge, Massachusetts, 02142, US)
BOTELLA, Gabriel Martinez (17 Parmenter Road, Wayland, Massachusetts, 01778, US)
HARRISON, Boyd L. (9 Wheatston Court, Princeton Junction, New Jersey, 08550, US)
ROBICHAUD, Albert Jean (2 Earhart St, 915Cambridge, Massachusetts, 02141, US)
SALITURO, Francesco G. (25 Baker Drive, Marlborough, Massachusetts, 01752, US)
BERESIS, Richard Thomas (Apartment 2504, Building 1 199 Shimen,#2 Road, Shanghai 0, 200040, CN)
International Classes:
C07J3/00; A61K31/56; A61P25/00; A61P25/08; C07J17/00; C07J43/00
Domestic Patent References:
WO2014169831A12014-10-23
WO1995021617A11995-08-17
WO2014169832A12014-10-23
WO2006037016A22006-04-06
WO2014071449A12014-05-15
Other References:
See also references of EP 3224269A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (10th Floor, Building 110 Caihefang Road, Haidian District, Beijing 0, 100080, CN)
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