COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS

Title:

COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS

Document Type and Number:

WIPO Patent Application WO/2016/082789

Kind Code:

A1

Abstract:

Described herein are neuroactive steroids of the Formula (II) : or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and ----- are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e. g., such for inducing sedation and/or anesthesia.

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Inventors:

BOTELLA GABRIEL MARTINEZ (US)
HARRISON BOYD L (US)
ROBICHAUD ALBERT JEAN (US)
SALITURO FRANCESCO G (US)
BERESIS RICHARD THOMAS (CN)

Application Number:

PCT/CN2015/095765

Publication Date:

June 02, 2016

Filing Date:

November 27, 2015

Export Citation:

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Assignee:

SAGE THERAPEUTICS INC (US)
BOTELLA GABRIEL MARTINEZ (US)
HARRISON BOYD L (US)
ROBICHAUD ALBERT JEAN (US)
SALITURO FRANCESCO G (US)
BERESIS RICHARD THOMAS (CN)

International Classes:

C07J3/00; A61K31/56; A61P25/00; A61P25/08; C07J17/00; C07J43/00

Domestic Patent References:

WO2014169831A1	2014-10-23
WO1995021617A1	1995-08-17
WO2014169832A1	2014-10-23
WO2006037016A2	2006-04-06
WO2014071449A1	2014-05-15

Other References: