COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS

Title:

COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS

Document Type and Number:

WIPO Patent Application WO/2012/097330

Kind Code:

A3

Abstract:

Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent. In certain embodiments disclosed herein, the S1P promoting agent is selected from S1P, 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone (THI), biologically active derivatives of THI, and sphingosine analogs. Embodiments of the methods disclosed herein include administering therapeutically effective amounts to subjects suffering from a degenerative muscle condition, such as, for example, subjects suffering from sarcopenia and subjects suffering from muscular dystrophy, including subjects suffering from Duchenne Muscular Dystrophy and Becker Muscular Dystrophy.

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Inventors:

LERONIMAKIS NICHOLAS (US)
RUOHOLA-BAKER HANNELE (US)
REYES MORAYMA (US)
QI JUNLIN (US)
PANTOJA MARIO (US)
FISCHER KARIN (US)

Application Number:

PCT/US2012/021362

Publication Date:

November 01, 2012

Filing Date:

January 13, 2012

Export Citation:

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Assignee:

UNIV WASHINGTON (US)
LERONIMAKIS NICHOLAS (US)
RUOHOLA-BAKER HANNELE (US)
REYES MORAYMA (US)
QI JUNLIN (US)
PANTOJA MARIO (US)
FISCHER KARIN (US)

International Classes:

A61K31/4178; A61K31/4164; A61P21/00

Domestic Patent References:

WO2010055028A2	2010-05-20
WO2010010127A1	2010-01-28

Foreign References:

US20090030050A1	2009-01-29
US20090068180A1	2009-03-12

Other References:

CHIARA DONATI ET AL.: "Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor", THE FASEB JOURNAL, vol. 19, no. 3, 2005, pages 449 - 451, XP008119605, DOI: doi:10.1096/fj.04-1780fje

Attorney, Agent or Firm:

WEBB, Samuel et al. (600 University Street Suite 360, Seattle Washington, US)

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