Title:
COMPOSITIONS AND METHODS FOR TREATING HYPERIMMUNE RESPONSE IN THE EYE
Document Type and Number:
WIPO Patent Application WO2005016263
Kind Code:
A3
Abstract:
The present invention comprises and utilizes methods and compositions for treating hyperimmune reactions in the eye. Compositions comprising antibodies to gamma interferon alone and in combination with antibodies to TNF alpha and other drugs are described. Also disclosed in the invention are methods of applying a composition comprising interferon gamma antibodies and TNF alpha antibodies, alone and in combination, topically to the eye to treat hyperimmune reactions, such as transplant rejection, autoimmune diseases of the eye, and ocular disorders incidental to or connected with autoimmune diseases.
Inventors:
SKURKOVICH BORIS (US)
SKURKOVICH SIMON (US)
SKURKOVICH SIMON (US)
Application Number:
PCT/US2004/024736
Publication Date:
May 19, 2005
Filing Date:
July 29, 2004
Export Citation:
Assignee:
ADVANCED BIOTHERAPY INC (US)
SKURKOVICH BORIS (US)
SKURKOVICH SIMON (US)
SKURKOVICH BORIS (US)
SKURKOVICH SIMON (US)
International Classes:
A61K39/395; A61K39/40; C07K16/24; A61K; (IPC1-7): A61K39/395; A61K39/40
Domestic Patent References:
| WO1990010707A1 | 1990-09-20 |
Foreign References:
| US20010021380A1 | 2001-09-13 |
Other References:
SKURKOVICH S. ET AL.: "Treatment of corneal transplant rejection in humans with anti-interferon gamma antibodies", AM.J. OPHTHALMOL., vol. 133, no. 6, June 2002 (2002-06-01), pages 829 - 830, XP002985426
STEVENS H.P.J.D. ET AL.: "Synergistic immunoprogressive effects of monoclonal antibodies specific for interferon-gamma and tumor necrosis factor alpha. A skin transplantation study in the rhesus monkey", TRANSPLANTATION, vol. 50, no. 5, November 1990 (1990-11-01), pages 856 - 861, XP008043402
STEVENS H.P.J.D. ET AL.: "Synergistic immunoprogressive effects of monoclonal antibodies specific for interferon-gamma and tumor necrosis factor alpha. A skin transplantation study in the rhesus monkey", TRANSPLANTATION, vol. 50, no. 5, November 1990 (1990-11-01), pages 856 - 861, XP008043402
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