Title:
COMPOSITIONS AND METHODS FOR TREATMENT OF CYTOKINE STORM AND RELATED CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2023/137331
Kind Code:
A3
Abstract:
Methods for treating a cytokine storm, sepsis, COVID-19, and/or ciliopathy comprise administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof. Methods for modulating an activity of C-terminal Src kinase (CSK) are further provided and comprise contacting a cell with a polypeptide antagonist of a Na/K ATPase/Src receptor complex. Methods for screening for peptidomimetics that target Src phosphorylation by CSK are also provided and include steps of contacting a cell with an effective amount of a test peptidomimetic having at least 75% homology to the amino acid sequence of SEQ ID NO: 1; and detecting an expression level or activity level of CSK or an amount of phosphorylation or Src in the cell in the presence of the test peptidomimetic.
Inventors:
CHIN KHEW-VOON (US)
SODHI KOMAL (US)
SHAPIRO JOSEPH (US)
SODHI KOMAL (US)
SHAPIRO JOSEPH (US)
Application Number:
PCT/US2023/060487
Publication Date:
August 24, 2023
Filing Date:
January 11, 2023
Export Citation:
Assignee:
MARSHALL UNIV RESEARCH CORPORATION (US)
International Classes:
C07K7/08; A61K38/10
Foreign References:
| US20200157568A1 | 2020-05-21 | |||
| US20150133389A1 | 2015-05-14 |
Attorney, Agent or Firm:
WRIGHT, Terry L. et al. (US)
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