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Title:
COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES OF THE LUNG
Document Type and Number:
WIPO Patent Application WO/2013/190497
Kind Code:
A3
Abstract:
The invention provides pharmaceutical compositions and methods for treatment of an inflammatory disease of the lung caused by inhalation of a toxic agent or an irritant, more particularly, chlorine inhalational lung injury, as well as certain compounds of formulae (II) and (I) that are useful in such compositions and methods.

Inventors:
SALZMAN ANDREW LURIE (US)
JAGTAP PRAKASH (US)
SOUTHAN GARRY JOHN (US)
Application Number:
IB2013/055067
Publication Date:
March 13, 2014
Filing Date:
June 20, 2013
Export Citation:
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Assignee:
RADIKAL THERAPEUTICS INC (US)
International Classes:
C07D203/18; A61K31/396; A61K31/397; A61K31/401; A61K31/404; A61K31/495; A61P29/02; C07D205/04; C07D207/16; C07D209/18; C07D209/52; C07D211/36
Domestic Patent References:
WO2011141909A22011-11-17
WO2011092690A12011-08-04
WO2007071442A22007-06-28
Foreign References:
JPH1112138A1999-01-19
Other References:
SO RI KIM ET AL: "A Novel Dithiol Amide CB3 Attenuates Allergic Airway Disease through Negative Regulation of p38 Mitogen-activated Protein Kinase", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 183, no. 8, 15 April 2011 (2011-04-15), pages 1015 - 1024, XP055078158, ISSN: 1073-449X, DOI: 10.1164/rccm.200906-0902OC
ZHANG X ET AL: "2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 18, no. 4, 15 February 2010 (2010-02-15), pages 1536 - 1554, XP026894817, ISSN: 0968-0896, [retrieved on 20100113], DOI: 10.1016/J.BMC.2010.01.009
P. GOCKEL ET AL: "Solution behaviour and zinc complexation of tripeptides with cysteine and/or histidine at both termini", INORGANICA CHIMICA ACTA, vol. 272, no. 1-2, 1 May 1998 (1998-05-01), pages 115 - 124, XP055078206, ISSN: 0020-1693, DOI: 10.1016/S0020-1693(97)05875-1
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