Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRAS ASSOCIATED DISEASES OR DISORDERS
Document Type and Number:
WIPO Patent Application WO/2020/205473
Kind Code:
A8
Abstract:
Provided herein are methods of treating a KRAS-associated cancer in a subject, comprising administering to the subject a therapeutically-effective amount of a KRAS nucleic acid inhibitor molecule and a therapeutically-effective amount of an MEK inhibitor or an immunotherapeutic agent. Also disclosed herein is a method of potentiating a therapeutic effect of an immunotherapeutic agent against a KRAS-associated cancer, comprising administering to a subject having the KRAS-associated cancer a KRAS nucleic acid inhibitor molecule in an amount sufficient to potentiate the therapeutic effect of the immunotherapeutic agent against the cancer.
Inventors:
GANESH SHANTHI (US)
Application Number:
PCT/US2020/025125
Publication Date:
October 07, 2021
Filing Date:
March 27, 2020
Export Citation:
Assignee:
DICERNA PHARMACEUTICALS INC (US)
International Classes:
C12N15/113; A61K31/519; A61K31/713; C07K16/28; A61P35/00
Attorney, Agent or Firm:
DONALDSON, Timothy, B. (US)
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