Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR
Document Type and Number:
WIPO Patent Application WO2000053755
Kind Code:
A3
Abstract:
The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Inventors:
ASHKENAZI AVI J (US)
BAKER KEVIN P (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
ROY MARGARET ANN (US)
WATANABE COLIN K (US)
WOOD WILLIAM I (US)
BAKER KEVIN P (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
ROY MARGARET ANN (US)
WATANABE COLIN K (US)
WOOD WILLIAM I (US)
Application Number:
PCT/US2000/000376
Publication Date:
February 08, 2001
Filing Date:
January 06, 2000
Export Citation:
Assignee:
GENENTECH INC (US)
ASHKENAZI AVI J (US)
BAKER KEVIN P (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
ROY MARGARET ANN (US)
WATANABE COLIN K (US)
WOOD WILLIAM I (US)
ASHKENAZI AVI J (US)
BAKER KEVIN P (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
ROY MARGARET ANN (US)
WATANABE COLIN K (US)
WOOD WILLIAM I (US)
International Classes:
C07K14/47; C07K14/705; C07K16/18; C12N15/12; A61K38/00; (IPC1-7): C12N15/12; A61K39/395; C07K14/47; C07K14/705; C07K16/18; C12N15/11; C12N15/62; C12Q1/68; G01N33/574
Domestic Patent References:
| WO1999004001A1 | 1999-01-28 | |||
| WO1998030694A2 | 1998-07-16 | |||
| WO1994000603A1 | 1994-01-06 | |||
| WO1993020238A2 | 1993-10-14 | |||
| WO1999014330A1 | 1999-03-25 |
Foreign References:
| EP0861850A1 | 1998-09-02 |
Other References:
PITTI, R.M. ET AL.: "Genomic amplification of a decoy receptor for FAS ligand in lung and colon cancer.", NATURE, vol. 396, 17 December 1998 (1998-12-17), pages 699 - 703, XP002139977
COLLINS V: "Gene amplification in human gliomas", GLIA,US,WILEY-LISS, NEW YORK, NY, vol. 15, no. 3, November 1995 (1995-11-01), pages 289 - 296-96, XP002109702, ISSN: 0994-1491
COLLINS V: "Gene amplification in human gliomas", GLIA,US,WILEY-LISS, NEW YORK, NY, vol. 15, no. 3, November 1995 (1995-11-01), pages 289 - 296-96, XP002109702, ISSN: 0994-1491
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