Title:
COMPOSITIONS AND METHODS FOR UPREGULATING HIPPOCAMPAL PLASTICITY AND HIPPOCAMPUS-DEPENDENT LEARNING AND MEMORY
Document Type and Number:
WIPO Patent Application WO/2015/013451
Kind Code:
A3
Abstract:
Provided are methods for enhancing hippocampal plasticity and hippocampal-mediated learning and memory, and/or enhancing the synaptic maturation of neurons, and/or optimizing or enhancing neuronal synaptic transmission, and/or enhancing intracellular oxygen delivery or utilization, and/or enhancing ATP synthesis, comprising administration, to a subject in need thereof of a sufficient amount over a sufficient time, of an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures (e.g., nanobubbles) having an average diameter of less than 100 nm (e.g., in at least one subject group selected from but not limited to normal subjects, subjects recovering from neurological trauma (e.g., accidents or injury to the brain, stroke, oxygen deprivation, drowning, and asphyxia), and subjects with learning disorders (e.g., dyslexia, dyscalculia, dysgraphia, dyspraxia (sensory integration disorder), dysphasia/aphasia, auditory processing disorder, non-verbal learning disorder, visual processing disorder, and attention deficit disorder (ADD)).
Inventors:
WATSON RICHARD L (US)
WOOD ANTHONY B (US)
ARCHAMBEAU GREGORY J (US)
GHOSH SUPURNA (US)
WOOD ANTHONY B (US)
ARCHAMBEAU GREGORY J (US)
GHOSH SUPURNA (US)
Application Number:
PCT/US2014/047892
Publication Date:
March 26, 2015
Filing Date:
July 23, 2014
Export Citation:
Assignee:
REVALESIO CORP (US)
International Classes:
A61K33/00; A61K9/00; A61K31/58; A61P25/28
Foreign References:
| US20100310609A1 | 2010-12-09 | |||
| US20120077751A1 | 2012-03-29 |
Other References:
BI ET AL.: "N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease.", J NEUROL SCI, vol. 200, no. 1-2, 15 August 2002 (2002-08-15), pages 11 - 18, XP055311176
ROHRER ET AL.: "Alzheimer's pathology in primary progressive aphasia.", NEUROBIOL AGING., vol. 33, no. 4, April 2012 (2012-04-01), pages 744 - 52, XP055311178
HARRIS ET AL.: "Synaptic energy use and supply.", NEURON., vol. 75, no. 5, 6 September 2012 (2012-09-06), pages 762 - 777, XP028456235
ROHRER ET AL.: "Alzheimer's pathology in primary progressive aphasia.", NEUROBIOL AGING., vol. 33, no. 4, April 2012 (2012-04-01), pages 744 - 52, XP055311178
HARRIS ET AL.: "Synaptic energy use and supply.", NEURON., vol. 75, no. 5, 6 September 2012 (2012-09-06), pages 762 - 777, XP028456235
Attorney, Agent or Firm:
DAVISON, Barry L. et al. (c/o IP Docketing Dept.1201 Third Avenue, Suite 220, Seattle Washington, US)
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