Title:
COMPOSITIONS, METHODS AND USES FOR DISEASE DIAGNOSIS
Document Type and Number:
WIPO Patent Application WO/2010/093731
Kind Code:
A3
Abstract:
Embodiments of the present invention generally related to methods and compositions for diagnosing or predicting a genetic disorder. In certain embodiments, the methods may include use of rapid and inexpensive assay systems. Other embodiments concern novel mutation specific peptides associated with BRCA1 or BRCA2. In yet other embodiments, haploid cells are used to diagnose a genetic disorder in a subject.
Inventors:
HOLT JEFFREY (US)
GIBSON KIMBERLY A (US)
GIBSON KIMBERLY A (US)
Application Number:
PCT/US2010/023800
Publication Date:
October 21, 2010
Filing Date:
February 10, 2010
Export Citation:
Assignee:
TISSUE GENETICS INC (US)
HOLT JEFFREY (US)
GIBSON KIMBERLY A (US)
HOLT JEFFREY (US)
GIBSON KIMBERLY A (US)
International Classes:
A61K38/04
Other References:
O'DONNELL ET AL.: "BRCA1 185delAG truncation protein, BRAt, amplifies caspase-mediated apoptosis in ovarian cells.", LN VITRO CELL. DEV. BIOL., vol. 44, 2008, pages 357 - 367, XP055171146, DOI: doi:10.1007/s11626-008-9122-0
OZCELIK ET AL.: "Heteroduplex and protein truncation analysis of the BRCA1 185delAG mutation.", HUMAN GENETICS, vol. 98, 1996, pages 310 - 312
OZCELIK ET AL.: "Heteroduplex and protein truncation analysis of the BRCA1 185delAG mutation.", HUMAN GENETICS, vol. 98, 1996, pages 310 - 312
Attorney, Agent or Firm:
HANSON, Roberta Jean (2200 Wells Fargo Center 90 South Seventh StreetMinneapolis, Minnesota, US)
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