Title:
COMPOSITIONS AND METHODS OF USING INTERLEUKIN-4 INDUCED GENE 1 (IL4I1)
Document Type and Number:
WIPO Patent Application WO/2016/040488
Kind Code:
A3
Abstract:
The invention is directed to methods of promoting myelin formation in central nervous system (CNS) tissue in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of interleukin-4 induced gene 1 (IL4-i1) protein. The invention is also directed to methods of monitoring the progression of conditions marked by an impairment of myelin formation in the CNS comprising assessing the levels or activity of IL4-i1 in activated macrophages obtained from the subject.
Inventors:
HUANG JEFFREY (US)
Application Number:
PCT/US2015/049196
Publication Date:
September 01, 2016
Filing Date:
September 09, 2015
Export Citation:
Assignee:
UNIV GEORGETOWN (US)
International Classes:
A61K38/43; A61P25/28; G01N33/68
Domestic Patent References:
| WO2007047335A2 | 2007-04-26 | |||
| WO2015035261A1 | 2015-03-12 |
Foreign References:
| CA2899961A1 | 2014-08-21 | |||
| US20140030734A1 | 2014-01-30 |
Other References:
PUIFFE, ML ET AL.: "Antibacterial Properties Of the Mammalian L-Amino Acid Oxidase IL 4I1.", PLOS ONE., vol. 8, no. 1, 23 January 2013 (2013-01-23), pages 5, XP055384626
ZHANG, H ET AL.: "Central Nervous System Remyelination In Culture - A Tool For Multiple Sclerosis Research.", EXP NEUROL., vol. 230, no. 1, July 2011 (2011-07-01), pages 138 - 148, XP055261770, DOI: doi:10.1016/j.expneurol.2011.04.009
ZHANG, H ET AL.: "Central Nervous System Remyelination In Culture - A Tool For Multiple Sclerosis Research.", EXP NEUROL., vol. 230, no. 1, July 2011 (2011-07-01), pages 138 - 148, XP055261770, DOI: doi:10.1016/j.expneurol.2011.04.009
Attorney, Agent or Firm:
BUCK, Todd B. et al. (Lewis & Bockius LLP1111 Pennsylvania Avenue, N, Washington District of Columbia, US)
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