COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE

WIPO Patent Application WO/2010/007376

A3

The disclosure relates to a monovalent polypeptide domain which specifically binds CD28, as well as to an antagonist of CD28, where the antagonist comprises a monovalent polypeptide domain which specifically binds CD28. This disclosure encompasses monovalent polypeptide domains comprising an antibody single variable domain that monovalently binds CD28. An antibody single variable domain that is monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a monovalent anti-CD28 antibody single variable domain consists of or comprises an antibody single variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the monovalent anti-CD28 antibody single variable domain is a human antibody single variable domain. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a monovalent anti-CD28 antibody single variable domain to the individual.

ENEVER CAROLYN (GB)
GRANT STEVEN (GB)
SANSOM DAVID (GB)
HOLMES STEVE (GB)

PCT/GB2009/001762

May 27, 2010

July 17, 2009

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DOMANTIS LTD (GB)
ENEVER CAROLYN (GB)
GRANT STEVEN (GB)
SANSOM DAVID (GB)
HOLMES STEVE (GB)

C07K16/28; A61K39/395; A61P37/06

WO2008071447A2	2008-06-19
WO2006030220A1	2006-03-23

US20050249700A1

2005-11-10

SMITH, Stephen, Edward (Park View House58 The Ropewalk, Nottingham NG1 5DD, GB)

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