Title:
COMPOSITIONS OF O-GLYCOSYL FLAVONOIDS
Document Type and Number:
WIPO Patent Application WO/2019/208574
Kind Code:
A1
Abstract:
A composition containing L-arginine and a glycosyl compound of formula (I): in which R is a moiety formed of a monosaccharide, a disaccharide, or an oligosaccharide including three to five monosaccharides; and the composition contains the glycosyl compound and L-arginine in a molar ratio of 1:1.6 to 1:3.0. Also disclosed is a method for preparing such a composition, as well as a composition prepared by the method.
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Inventors:
YAMAGUCHI NAOTO (JP)
KIDA HIROAKI (JP)
KIDA HIROAKI (JP)
Application Number:
PCT/JP2019/017262
Publication Date:
October 31, 2019
Filing Date:
April 23, 2019
Export Citation:
Assignee:
ALPS PHARMACEUTICAL IND CO LTD (JP)
International Classes:
A61K31/7048; A23L33/10; A61K8/00; A61K47/18
Domestic Patent References:
WO2010110328A1 | 2010-09-30 |
Foreign References:
RU2545905C1 | 2015-04-10 | |||
JP2008092869A | 2008-04-24 | |||
EP1669462A1 | 2006-06-14 | |||
US20120083460A1 | 2012-04-05 | |||
US20120083460A1 | 2012-04-05 | |||
JP2926411B2 | 1999-07-28 | |||
US2646428A | 1953-07-21 | |||
US2451772A | 1948-10-19 | |||
US20100204204A1 | 2010-08-12 |
Other References:
ÇELIK SALIHA ESIN ET AL: "Antioxidant capacity of quercetin and its glycosides in the presence of [beta]-cyclodextrins: influence of glycosylation on inclusion complexation", JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, KLUWER, DORDRECHT, NL, vol. 83, no. 3, 1 October 2015 (2015-10-01), pages 309 - 319, XP035913950, ISSN: 1388-3127, [retrieved on 20151001], DOI: 10.1007/S10847-015-0566-Z
ROSARIA ACQUAVIVA ET AL: "Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 296, no. 3, 1 March 2009 (2009-03-01), US, pages G664 - G670, XP055603948, ISSN: 0193-1857, DOI: 10.1152/ajpgi.90609.2008
ROSARIA ACQUAVIVA ET AL: "Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 296, no. 3, 1 March 2009 (2009-03-01), US, pages G664 - G670, XP055603948, ISSN: 0193-1857, DOI: 10.1152/ajpgi.90609.2008
Attorney, Agent or Firm:
HATTA & ASSOCIATES (JP)
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