Title:
COMPOSITIONS OF POLYACIDS AND POLYETHERS AND METHODS FOR THEIR USE IN REDUCING PAIN
Document Type and Number:
WIPO Patent Application WO2005027852
Kind Code:
A3
Abstract:
The present invention relates to improved methods for reducing pain and organ dysfunction using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then either dried into membranes or sponges, or are used as gels, fluids or microspheres. Compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. Anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.
Inventors:
SCHWARTZ HERBERT E (US)
BLACKMORE JOHN M (US)
CORTESE STEPHANIE M (US)
OPPELT WILLIAM G (US)
DIZEGERA GERE (US)
BLACKMORE JOHN M (US)
CORTESE STEPHANIE M (US)
OPPELT WILLIAM G (US)
DIZEGERA GERE (US)
Application Number:
PCT/US2004/030839
Publication Date:
October 27, 2005
Filing Date:
September 20, 2004
Export Citation:
Assignee:
FZIOMED INC (US)
SCHWARTZ HERBERT E (US)
BLACKMORE JOHN M (US)
CORTESE STEPHANIE M (US)
OPPELT WILLIAM G (US)
DIZEGERA GERE (US)
SCHWARTZ HERBERT E (US)
BLACKMORE JOHN M (US)
CORTESE STEPHANIE M (US)
OPPELT WILLIAM G (US)
DIZEGERA GERE (US)
International Classes:
A61K9/00; A61K47/00; A61K47/10; A61K47/36; A61L29/08; A61L31/04; A61L31/14; A61L33/06; C08B11/20; C08B15/00; C08B37/00; C08L1/28; C08L5/00; C08L71/02; A61K9/16; A61K9/70; A61K; (IPC1-7): A61K47/00
Domestic Patent References:
| WO1997001345A1 | 1997-01-16 |
Foreign References:
| US5800832A | 1998-09-01 | |||
| US5985312A | 1999-11-16 |
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