Title:
COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE VARIANTS AND METHODS OF USING COMPOSITIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/097335
Kind Code:
A3
Abstract:
Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.
Inventors:
OKHAMAFE AUGUSTUS O (US)
BELL SEAN M (US)
ZECHERLE G NICK (US)
ANTONSEN KRIS (US)
ZHANG YANHONG (US)
LY KIEU Y (US)
FITZPATRICK PAUL A (US)
KAKKIS EMIL D (US)
VELLARD MICHEL CLAUDE (US)
WENDT DANIEL J (US)
MUTHALIF MUBARACK (US)
BELL SEAN M (US)
ZECHERLE G NICK (US)
ANTONSEN KRIS (US)
ZHANG YANHONG (US)
LY KIEU Y (US)
FITZPATRICK PAUL A (US)
KAKKIS EMIL D (US)
VELLARD MICHEL CLAUDE (US)
WENDT DANIEL J (US)
MUTHALIF MUBARACK (US)
Application Number:
PCT/US2011/023534
Publication Date:
October 20, 2011
Filing Date:
February 03, 2011
Export Citation:
Assignee:
BIOMARIN PHARM INC (US)
OKHAMAFE AUGUSTUS O (US)
BELL SEAN M (US)
ZECHERLE G NICK (US)
ANTONSEN KRIS (US)
ZHANG YANHONG (US)
LY KIEU Y (US)
FITZPATRICK PAUL A (US)
KAKKIS EMIL D (US)
VELLARD MICHEL CLAUDE (US)
WENDT DANIEL J (US)
MUTHALIF MUBARACK (US)
OKHAMAFE AUGUSTUS O (US)
BELL SEAN M (US)
ZECHERLE G NICK (US)
ANTONSEN KRIS (US)
ZHANG YANHONG (US)
LY KIEU Y (US)
FITZPATRICK PAUL A (US)
KAKKIS EMIL D (US)
VELLARD MICHEL CLAUDE (US)
WENDT DANIEL J (US)
MUTHALIF MUBARACK (US)
International Classes:
C07K1/00
Foreign References:
| US20090047265A1 | 2009-02-19 | |||
| US20040126358A1 | 2004-07-01 | |||
| US20080274952A1 | 2008-11-06 | |||
| US20080064856A1 | 2008-03-13 | |||
| US5466781A | 1995-11-14 | |||
| US20050163708A1 | 2005-07-28 |
Other References:
"Process Media Products Toyopearl GigaCap Q-650.", TOSOH BIOSCIENCE LLC., 20 November 2008 (2008-11-20), pages 1 - 2, Retrieved from the Internet [retrieved on 20110802]
Attorney, Agent or Firm:
RIEGER, Dale, L. et al. (222 East 41st StreetNew York, NY, US)
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