Title:
COMPOSITIONS FOR PROTECTION AGAINST BOVINE VIRAL DISEASES
Document Type and Number:
WIPO Patent Application WO2002041921
Kind Code:
A3
Abstract:
The present invention relates to methods and compositions for eliciting an immune response against bovine viral epitopes. The methods comprise combining at least one heat shock protein with at least one bovine viral epitope to form a purified epitope/heat shock protein complex and administration of an immune system stimulating amount of the purified epitope/heat shock protein complex. The compositions comprise, a purified epitope/heat shock protein complex comprising at least one bovine viral epitope complexed with at least one heat shock protein, and a pharmaceutically acceptable carrier, diluent or excipient.
Inventors:
SRIKUMARAN SUBRAMANIAM
Application Number:
PCT/US2001/045781
Publication Date:
August 28, 2003
Filing Date:
November 02, 2001
Export Citation:
Assignee:
UNIV NEBRASKA (US)
International Classes:
A61K39/385; A61K39/39; A61K47/48; C07K14/06; (IPC1-7): A61K47/48; A61K39/395
Domestic Patent References:
| WO2001034184A2 | 2001-05-17 |
Other References:
ZATECHKA D S JR ET AL: "Identification of murine cytotoxic T-lymphocyte epitopes of bovine herpesvirus 1.", VACCINE. ENGLAND 26 FEB 1999, vol. 17, no. 7-8, 26 February 1999 (1999-02-26), pages 686 - 694, XP002237337, ISSN: 0264-410X
BARRIOS C ET AL: "Heat shock proteins as carrier molecules: in vivo helper effect mediated by Escherichia coli GroEL and DnaK proteins requires cross-linking with antigen.", CLINICAL AND EXPERIMENTAL IMMUNOLOGY. ENGLAND NOV 1994, vol. 98, no. 2, November 1994 (1994-11-01), pages 229 - 233, XP000965591, ISSN: 0009-9104
NAVARATNAM MANJULA ET AL: "Heat shock protein-peptide complexes elicit cytotoxic T-lymphocyte and antibody responses specific for bovine herpesvirus 1.", VACCINE, vol. 19, no. 11-12, 2001, pages 1425 - 1434, XP002237338, ISSN: 0264-410X
BARRIOS C ET AL: "Heat shock proteins as carrier molecules: in vivo helper effect mediated by Escherichia coli GroEL and DnaK proteins requires cross-linking with antigen.", CLINICAL AND EXPERIMENTAL IMMUNOLOGY. ENGLAND NOV 1994, vol. 98, no. 2, November 1994 (1994-11-01), pages 229 - 233, XP000965591, ISSN: 0009-9104
NAVARATNAM MANJULA ET AL: "Heat shock protein-peptide complexes elicit cytotoxic T-lymphocyte and antibody responses specific for bovine herpesvirus 1.", VACCINE, vol. 19, no. 11-12, 2001, pages 1425 - 1434, XP002237338, ISSN: 0264-410X
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