Title:
COMPOSITIONS FOR RECOVERING OR AMELIORATING DETERIORATION OF PHYSIOLOGICAL FUNCTIONS DUE TO AGING
Document Type and Number:
WIPO Patent Application WO/2017/115789
Kind Code:
A1
Abstract:
Provided are compositions for recovering and/or ameliorating deterioration of physiological functions due to aging. A cell overexpressing GDF6 protein or an miR-17 family member. A composition for treating aging-related symptoms, said composition comprising GDF6 protein. A composition for treating aging-related symptoms, said composition comprising a human expression vector of GDF6 protein or an miR-17 family member. A composition for treating aging-related symptoms, said composition comprising a cell secreting GDF6 protein.
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Inventors:
KANEDA YUTO (JP)
Application Number:
PCT/JP2016/088865
Publication Date:
July 06, 2017
Filing Date:
December 27, 2016
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
A61K38/22; A61K31/7105; A61K35/28; A61K35/76; A61K48/00; A61P7/00; A61P9/14; A61P17/00; A61P21/00; A61P25/00; A61P43/00; C12N5/10
Domestic Patent References:
| WO2013162027A1 | 2013-10-31 |
Foreign References:
| JP2015509366A | 2015-03-30 | |||
| JP2008519606A | 2008-06-12 |
Other References:
HACKL M. ET AL.: "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging", AGING CELL, vol. 9, 2010, pages 291 - 296, XP002658047
WANG M. ET AL.: "Differential expression of oncogenic miRNAs in proliferating and senescent human fibroblasts", MOLL. CELL . BIOCHEM., vol. 352, 2011, pages 271 - 279, XP019904316
WOLFMAN M.N. ET AL.: "Ectopic induction of tendon and ligament in rats by growth and differntiation factors 5,6, and 7, menbers of the TGF-beta gene family", J.CLIN.INVEST., vol. 100, 1997, pages 321 - 330, XP055396939
HISAMITSU D. ET AL.: "Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues", AGING, vol. 8, June 2016 (2016-06-01), pages 1259 - 1269, XP055396941
WANG M. ET AL.: "Differential expression of oncogenic miRNAs in proliferating and senescent human fibroblasts", MOLL. CELL . BIOCHEM., vol. 352, 2011, pages 271 - 279, XP019904316
WOLFMAN M.N. ET AL.: "Ectopic induction of tendon and ligament in rats by growth and differntiation factors 5,6, and 7, menbers of the TGF-beta gene family", J.CLIN.INVEST., vol. 100, 1997, pages 321 - 330, XP055396939
HISAMITSU D. ET AL.: "Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues", AGING, vol. 8, June 2016 (2016-06-01), pages 1259 - 1269, XP055396941
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
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