COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS OR ANTIGEN PRESENTING CELLS, METHODS AND USES THEREOF - CENTRO DE NEUROCIENCIAS E BIOLOGIA CELULAR

Title:

COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS OR ANTIGEN PRESENTING CELLS, METHODS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/185709

Kind Code:

A9

Abstract:

The present disclosure relates to compositions, nucleic acid constructs, methods and kits thereof for cell induction or reprogramming cells to the dendritic cell state or antigen presenting cell state, based, in part, on the surprisingly effect described herein of novel use and combinations of transcription factors that permit induction or reprogramming of differentiated or undifferentiated cells into dendritic cells or antigen presenting cells. Such compositions, nucleic acid constructs, methods and kits can be used for inducing dendritic cells in vitro, ex vivo, or in vivo, and these induced dendritic cells or antigen presenting cells can be used for immunotherapy applications.

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Inventors:

RIBEIRO LEMOS PEREIRA CARLOS FILIPE (PT)
FERREIRA PIRES CRISTIANA (PT)
FIÚZA ROSA FÁBIO ALEXANDRE (PT)

Application Number:

PCT/IB2018/052378

Publication Date:

August 22, 2019

Filing Date:

April 05, 2018

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Assignee:

CENTRO DE NEUROCIENCIAS E BIOLOGIA CELULAR (PT)

International Classes:

C12N5/0784; A61K35/15; A61K38/17; C07K14/47

Attorney, Agent or Firm:

HØIBERG P/S (DK)

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