COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS

WIPO Patent Application WO2004050858

A3

The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.

MACINA ROBERTO A (US)
TURNER LEAH R (US)
SUN YONGMING (US)
RODRIGUEZ MARIA (US)
BURCHAM TIMOTHY S (US)

PCT/US2003/038808

November 18, 2004

December 04, 2003

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DIADEXUS INC (US)
MACINA ROBERTO A (US)
TURNER LEAH R (US)
SUN YONGMING (US)
RODRIGUEZ MARIA (US)
BURCHAM TIMOTHY S (US)

C07K14/47; C12N15/12; (IPC1-7): C12Q1/68; C12P21/02; C12N15/00; C12N15/12; C12N15/11; A61K31/7088; A61K31/711

WO1995015084A1

1995-06-08

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