COMPOSITIONS FOR TRANSFECTION OF BIOMOLECULES INTO CELLS

Title:

COMPOSITIONS FOR TRANSFECTION OF BIOMOLECULES INTO CELLS

Document Type and Number:

WIPO Patent Application WO/2010/123798

Kind Code:

A3

Abstract:

The present invention is directed to new compositions that are described for the simultaneous, controlled dose delivery of a variety of biomolecules into phagocytic cells. Such a composition is a biologically active composition comprising: (1) at least one of the following biologically active components: (a) a nucleic acid or a derivative thereof; (b) a nucleoside, nucleotide, or a derivative of a nucleoside or nucleotide; (c) a peptide, protein, or a derivative of a peptide or protein; (d) a lipopolysaccharide or a derivative thereof; (e) a peptidoglycan or a derivative thereof; (f) a carbohydrate or a derivative thereof; (g) a lipid or a derivative thereof; (h) a lipopeptide or a derivative thereof; (i) a metal ion; (j) a thiol; (k) an antibiotic or a derivative thereof; (I) a vitamin or a derivative thereof; (m) a bioflavonoid or a derivative thereof; (n) an antioxidant or a derivative thereof; (o) an immune response modifier; (p) an antibody; (q) a biologically active nonmetal; (r) histamine or an antihistamine; and (s) a kinase inhibitor; and (2) at least one carrier effective to deliver the composition to a phagocytic cell such that the biologically active component is taken up by the phagocytic cell and influences its biological activity.

Inventors:

GRANDICS PETER (US)
SZATHMARY SUSAN (US)

Application Number:

PCT/US2010/031559

Publication Date:

March 10, 2011

Filing Date:

April 19, 2010

Export Citation:

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Assignee:

GALENBIO INC (US)
GRANDICS PETER (US)
SZATHMARY SUSAN (US)

International Classes:

C12N5/00

Foreign References:

US20070281036A1	2007-12-06
US20020090610A1	2002-07-11

Other References: