Title:
COMPOSITIONS FOR TREATMENT, DIAGNOSIS AND PROGNOSIS OF DISEASES
Document Type and Number:
WIPO Patent Application WO/2016/014992
Kind Code:
A3
Abstract:
Disclosed herein are novel pharmaceutically-useful compositions comprising an inhibitor of PIP5KIA, which compositions may be useful in the treatment of diseases such as cancer. Also disclosed is the use of the compositions for disease diagnosis and prognosis, treatment selection and disease progression monitoring.
Inventors:
PERSSON JENNY L (SE)
JOHNSON HEATHER H (US)
JOHNSON HEATHER H (US)
Application Number:
PCT/US2015/042084
Publication Date:
March 17, 2016
Filing Date:
July 24, 2015
Export Citation:
Assignee:
EVEREST BIOSCIENCES INC (US)
International Classes:
C12N15/113; A61K31/00; A61P35/00
Foreign References:
| US20030114400A1 | 2003-06-19 |
Other References:
LI ET AL.: "The ATM Inhibitor KU-55933 Suppresses Cell Proliferation and Induces Apoptosis by Blocking Akt In Cancer Cells with Overactivated Akt.", MOL CANCER THER, vol. 9, no. 1, January 2010 (2010-01-01), pages 113 - 125
VAN DEN BOUT ET AL.: "PIP5K-driven Ptdlns(4,5)P2 synthesis: regulation and cellular function.", J CELL SCI, vol. 122, no. 21, 1 November 2009 (2009-11-01), pages 3837 - 3850
MUSCOLINI ET AL.: "Phosphatidylinositol 4-Phosphate 5-Kinase alpha Activation Critically Contributes to CD 28-Dependent Signaling Responses.", THE JOURNAL OF IMMUNOLOGY, vol. 190, no. 10, 15 May 2013 (2013-05-15), pages 5279 - 5286
VAN DEN BOUT ET AL.: "PIP5K-driven Ptdlns(4,5)P2 synthesis: regulation and cellular function.", J CELL SCI, vol. 122, no. 21, 1 November 2009 (2009-11-01), pages 3837 - 3850
MUSCOLINI ET AL.: "Phosphatidylinositol 4-Phosphate 5-Kinase alpha Activation Critically Contributes to CD 28-Dependent Signaling Responses.", THE JOURNAL OF IMMUNOLOGY, vol. 190, no. 10, 15 May 2013 (2013-05-15), pages 5279 - 5286
Attorney, Agent or Firm:
CULLMAN, Louis, C. et al. (1 Park Plaza 12th Floo, Irvine CA, US)
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