Title:
COMPOSITIONS FOR USE IN THE TREATMENT OF MUTANT RECEPTOR TYROSINE KINASE DRIVEN CELLULAR PROLIFERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO2005058341
Kind Code:
A3
Abstract:
Uses of a CDK4 inhibitor in the manufacture of a medicament for treating a subject suffering from a cellular proliferative disease characterized by the presence of a mutant receptor tyrosine kinase are provided. The CDK4 inhibitor is for administration either alone or in combination with at least one of an inhibitor of the mutant receptor tyrosine kinase and an MEK inhibitor. Also provided are compositions, including pharmaceutical formulations and kits thereof, comprising the above inhibitors.
Inventors:
BRIESEWITZ ROGER (US)
Application Number:
PCT/US2004/041333
Publication Date:
December 08, 2005
Filing Date:
December 09, 2004
Export Citation:
Assignee:
THERAVANCE INC (US)
BRIESEWITZ ROGER (US)
BRIESEWITZ ROGER (US)
International Classes:
A61K31/00; A61K31/407; A61K45/06; (IPC1-7): A61P35/02
Domestic Patent References:
| WO2003076433A1 | 2003-09-18 | |||
| WO1999024416A1 | 1999-05-20 | |||
| WO2002057261A2 | 2002-07-25 | |||
| WO2004018419A2 | 2004-03-04 |
Other References:
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PERABO FRANK ET AL: "Flavopiridol mediates cell cycle arrest and apoptosis in bladder cancer cells but acts not synergistically with other cytotoxic agents", EUROPEAN UROLOGY, vol. 39, no. Suppl. 5, March 2001 (2001-03-01), & XVITH CONGRESS OF THE EUROPEAN ASSOCIATION OF UROLOGY; GENEVA, SWITZERLAND; APRIL 07-10, 2001, pages 172, XP009054271, ISSN: 0302-2838
DAI Y ET AL: "Cyclin-dependent kinase inhibitors", CURRENT OPINION IN PHARMACOLOGY 2003 UNITED KINGDOM, vol. 3, no. 4, August 2003 (2003-08-01), pages 362 - 370, XP002346558, ISSN: 1471-4892
TOPALY J ET AL: "Combination therapy with imatinib mesylate (STI571): synopsis of in vitro studies.", BRITISH JOURNAL OF HAEMATOLOGY. OCT 2002, vol. 119, no. 1, October 2002 (2002-10-01), pages 3 - 14, XP002346559, ISSN: 0007-1048
PEREIRA E R ET AL: "Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.", JOURNAL OF MEDICINAL CHEMISTRY. 25 OCT 1996, vol. 39, no. 22, 25 October 1996 (1996-10-25), pages 4471 - 4477, XP002346561, ISSN: 0022-2623
KERR A H J ET AL: "An investigation of the MEK/ERK inhibitor U0126 in acute myeloid leukemia.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. DEC 2003, vol. 1010, December 2003 (2003-12-01), pages 86 - 89, XP009054492, ISSN: 0077-8923
WEISBERG ELLEN ET AL: "Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.", CANCER CELL. JUN 2002, vol. 1, no. 5, June 2002 (2002-06-01), pages 433 - 443, XP002346669, ISSN: 1535-6108
PERABO FRANK ET AL: "Flavopiridol mediates cell cycle arrest and apoptosis in bladder cancer cells but acts not synergistically with other cytotoxic agents", EUROPEAN UROLOGY, vol. 39, no. Suppl. 5, March 2001 (2001-03-01), & XVITH CONGRESS OF THE EUROPEAN ASSOCIATION OF UROLOGY; GENEVA, SWITZERLAND; APRIL 07-10, 2001, pages 172, XP009054271, ISSN: 0302-2838
DAI Y ET AL: "Cyclin-dependent kinase inhibitors", CURRENT OPINION IN PHARMACOLOGY 2003 UNITED KINGDOM, vol. 3, no. 4, August 2003 (2003-08-01), pages 362 - 370, XP002346558, ISSN: 1471-4892
TOPALY J ET AL: "Combination therapy with imatinib mesylate (STI571): synopsis of in vitro studies.", BRITISH JOURNAL OF HAEMATOLOGY. OCT 2002, vol. 119, no. 1, October 2002 (2002-10-01), pages 3 - 14, XP002346559, ISSN: 0007-1048
PEREIRA E R ET AL: "Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.", JOURNAL OF MEDICINAL CHEMISTRY. 25 OCT 1996, vol. 39, no. 22, 25 October 1996 (1996-10-25), pages 4471 - 4477, XP002346561, ISSN: 0022-2623
KERR A H J ET AL: "An investigation of the MEK/ERK inhibitor U0126 in acute myeloid leukemia.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. DEC 2003, vol. 1010, December 2003 (2003-12-01), pages 86 - 89, XP009054492, ISSN: 0077-8923
WEISBERG ELLEN ET AL: "Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.", CANCER CELL. JUN 2002, vol. 1, no. 5, June 2002 (2002-06-01), pages 433 - 443, XP002346669, ISSN: 1535-6108
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