Title:
COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2017/171535
Kind Code:
A3
Abstract:
There is provided a solid pharmaceutical composition for delivering by oral administration a pharmaceutically active binding polypeptide to a region of the intestinal tract comprising a compressed core, wherein the compressed core comprises a pharmaceutically active binding polypeptide and wherein the compressed core is coated with a pH sensitive enteric coating.
Inventors:
CROWE SCOTT (GB)
WEST MIKE (GB)
ROBERTS KEVIN (GB)
CARLTON TIM (GB)
MAGGIORE LUANA (GB)
CUBITT MARION (GB)
WHALE GARY (GB)
WAHLICH JOHN (GB)
FRODSHAM MIKE (GB)
WEST MIKE (GB)
ROBERTS KEVIN (GB)
CARLTON TIM (GB)
MAGGIORE LUANA (GB)
CUBITT MARION (GB)
WHALE GARY (GB)
WAHLICH JOHN (GB)
FRODSHAM MIKE (GB)
Application Number:
PCT/MT2017/000001
Publication Date:
December 07, 2017
Filing Date:
April 03, 2017
Export Citation:
Assignee:
VHSQUARED LTD (GB)
DR SANSONE LUIGI A (MT)
DR SANSONE LUIGI A (MT)
International Classes:
A61K9/14; A61K9/16; A61K9/20; A61K9/50; A61K31/00; A61K38/00
Domestic Patent References:
| WO2014030049A2 | 2014-02-27 | |||
| WO2008122965A2 | 2008-10-16 |
Foreign References:
| US20100260857A1 | 2010-10-14 | |||
| US20060057197A1 | 2006-03-16 |
Other References:
SINGH DEEP HUSSAN ET AL: "A review on recent advances of enteric coating", IOSR JOURNAL OF PHARMACY, INTERNATIONAL ORGANIZATION OF SCIENTIFIC RESEARCH, IN, vol. 2, no. 6, 1 November 2012 (2012-11-01), pages 5 - 11, XP002743136, ISSN: 2319-4219
HARMSEN M M ET AL: "Selection and optimization of proteolytically stable llama single-domain antibody fragments for oral immunotherapy", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 72, no. 3, 1 February 2006 (2006-02-01), pages 544 - 551, XP019422023, ISSN: 1432-0614, DOI: 10.1007/S00253-005-0300-7
GREG HUSSACK ET AL: "Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability", PLOS ONE, vol. 6, no. 11, 30 November 2011 (2011-11-30), pages e28218, XP055179537, DOI: 10.1371/journal.pone.0028218
HARMSEN M M ET AL: "Selection and optimization of proteolytically stable llama single-domain antibody fragments for oral immunotherapy", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 72, no. 3, 1 February 2006 (2006-02-01), pages 544 - 551, XP019422023, ISSN: 1432-0614, DOI: 10.1007/S00253-005-0300-7
GREG HUSSACK ET AL: "Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability", PLOS ONE, vol. 6, no. 11, 30 November 2011 (2011-11-30), pages e28218, XP055179537, DOI: 10.1371/journal.pone.0028218
Attorney, Agent or Firm:
Dr. SANSONE, Luigi A. (MT)
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