COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYL OR HETEROARYL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF

Title:

COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYL OR HETEROARYL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/155358

Kind Code:

A1

Abstract:

Disclosed are a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, a preparation method thereof, pharmaceutical compositions and uses thereof in the preparation of a medicine for inhibiting HIF proline hydroxylase or a medicine for promoting the generation of endogenous EPO, wherein in the formula (I), R1 and R2 are each independently hydrogen; R3 is hydrogen or C1-3alkyl; and Ar is an aromatic ring or an heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring.

Inventors:

ZHOU YUNLONG (CN)
CAI SUIXIONG (US)
WANG GUANGFENG (CN)
JIAO LINGLING (CN)
MIN PING (CN)
JING YU (CN)
GUO MING (US)

Application Number:

PCT/CN2015/097245

Publication Date:

October 06, 2016

Filing Date:

December 14, 2015

Export Citation:

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Assignee:

SHENYANG SUNSHINE PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D471/04; A61K31/4375; A61K31/444; A61P1/00; A61P9/00; A61P21/00; A61P29/00

Domestic Patent References:

WO2007103905A2

2007-09-13

Foreign References:

CN103608346A	2014-02-26
CN101663037A	2010-03-03
CN101370502A	2009-02-18
CN101917996A	2010-12-15

Other References: