Title:
COMPOUND, ALDEHYDE DEHYDROGENASE 2 ACTIVATOR, PHARMACEUTICAL COMPOSITION, AND TREATMENT AND/OR PREVENTATIVE DRUG
Document Type and Number:
WIPO Patent Application WO/2022/092310
Kind Code:
A1
Abstract:
The present invention provides a compound, etc. which has aldehyde dehydrogenase 2 (ALDH2) activating activity. Provided are a compound represented by formula (1), a pharmaceutically acceptable salt thereof, and a prodrug thereof. [In the formula, A is a heterocyclic ring, R1 and R2 are each independently hydrogen, an alkyl, an alkenyl or an alkynyl; R3 is an alkyl, an alkenyl, or an alkynyl; and X1 and X2 are each independently a halogen.]
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Inventors:
TANAKA KEIGO (JP)
NINOMIYA TOMOHISA (JP)
NINOMIYA TOMOHISA (JP)
Application Number:
PCT/JP2021/040218
Publication Date:
May 05, 2022
Filing Date:
November 01, 2021
Export Citation:
Assignee:
ALCHEMEDICINE INC (JP)
International Classes:
C07D213/56; A61K31/415; A61K31/4418; A61K31/661; A61P1/16; A61P1/18; A61P7/06; A61P9/00; A61P9/10; A61P19/10; A61P25/04; A61P25/16; A61P25/28; A61P35/00; A61P43/00; C07D231/12; C07F9/09
Domestic Patent References:
| WO2019151241A1 | 2019-08-08 | |||
| WO2020076974A1 | 2020-04-16 | |||
| WO2008112164A2 | 2008-09-18 | |||
| WO2014160185A2 | 2014-10-02 | |||
| WO2015127137A1 | 2015-08-27 | |||
| WO2019151241A1 | 2019-08-08 |
Foreign References:
| JP2017507147A | 2017-03-16 | |||
| JP2016514154A | 2016-05-19 |
Other References:
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NUTRITION DIABETES, vol. 6, 2016, pages e210
REDOX BIOLOGY, vol. 24, 2019, pages 101205
JOURNAL OF HEPATOLOGY, vol. 62, 2015, pages 647 - 656
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 522, 2020, pages 518 - 524
PHARMACOLOGICAL RESEARCH, vol. 115, 2017, pages 96 - 106
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 273, 2000, pages 192 - 196
NEUROLOGY, vol. 82, 2014, pages 419 - 426
GASTROENTEROLOGY, vol. 151, 2016, pages 860 - 869
CARCINOGENESIS, vol. 41, 2020, pages 194 - 202
INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 32, 2008, pages 945 - 973
SCIENCE TRANSLATIONAL MEDICINE, vol. 6, 2014, pages 251ra118 - 118
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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