Title:
COMPOUND AS ACC INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/020041
Kind Code:
A1
Abstract:
Disclosed are a class of compounds which are inhibitors of acetyl-CoA carboxylase (ACC) and the use thereof. In particular, provided are compounds as shown in formula I or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, and methods for preparing the same, and pharmaceutical compositions comprising the compounds and the use of the compounds or compositions for treating and/or preventing diseases associated with ACC expression, such as fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases. The compound has a good inhibitory activity against ACC and shows good promise to be a therapeutic drug for fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases.
Inventors:
WANG YONG (CN)
ZHAO LIWEN (CN)
WANG YAZHOU (CN)
QUAN XU (CN)
JIANG CHUNHUAN (CN)
CHEN HONGYAN (CN)
CHEN MENGHUA (CN)
LI CHAO (CN)
LIAO YEXIN (CN)
LIU QI (CN)
WANG CHEN (CN)
WANG HAI (CN)
YANG SHENGWEI (CN)
ZHENG GUOCHUANG (CN)
ZHAO LIWEN (CN)
WANG YAZHOU (CN)
QUAN XU (CN)
JIANG CHUNHUAN (CN)
CHEN HONGYAN (CN)
CHEN MENGHUA (CN)
LI CHAO (CN)
LIAO YEXIN (CN)
LIU QI (CN)
WANG CHEN (CN)
WANG HAI (CN)
YANG SHENGWEI (CN)
ZHENG GUOCHUANG (CN)
Application Number:
PCT/CN2018/096930
Publication Date:
January 31, 2019
Filing Date:
July 25, 2018
Export Citation:
Assignee:
NANJING SANHOME PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D495/04; A61K31/519; A61P1/16; A61P3/04; A61P3/10; A61P35/00; C07D519/00
Domestic Patent References:
| WO2017075056A1 | 2017-05-04 | |||
| WO2013071169A1 | 2013-05-16 |
Foreign References:
| CN104105485A | 2014-10-15 | |||
| CN108341830A | 2018-07-31 |
Other References:
TONG LHARWOOD HJ JR., J CELL BIOCHEM., vol. 99, no. 6, 2006, pages 1476 - 1788
GERALDINE HARRIMANJEREMY GREENWOODSATHESH BHAT ET AL., PROC NATL ACAD SCI U.S.A., vol. 113, no. 13, 2016, pages E1796 - E1805
SVENSSON RUPARKER SJEICHNER LJ ET AL., NAT MED., vol. 22, no. 10, 2016, pages 1108 - 1119
See also references of EP 3660023A4
GERALDINE HARRIMANJEREMY GREENWOODSATHESH BHAT ET AL., PROC NATL ACAD SCI U.S.A., vol. 113, no. 13, 2016, pages E1796 - E1805
SVENSSON RUPARKER SJEICHNER LJ ET AL., NAT MED., vol. 22, no. 10, 2016, pages 1108 - 1119
See also references of EP 3660023A4
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
Download PDF:
Previous Patent: FOLDING SUPPORT USED ON BACKPACK SUNSHADE APPARATUS
Next Patent: INTELLIGENT LIQUID SOAP SUPPLY SYSTEM
Next Patent: INTELLIGENT LIQUID SOAP SUPPLY SYSTEM