COMPOUND AS NMT INHIBITOR AND USE THEREOF

WIPO Patent Application WO/2021/008512

A1

The present invention provides a compound having N-myristoyltransferase (NMT) inhibitor activity or a pharmaceutically acceptable salt thereof and a preparation method therefor. The present invention also relates to use of such compound as an N-myristoyltransferase (NMT) inhibitor for preparing a medicament for treating or preventing infectious diseases or hyperproliferative diseases. The infectious diseases include protozoan infections (such as malaria and leishmaniasis) and viral infections (such as human rhinovirus and HIV). The hyperproliferative diseases include lymphoma, leukemia, pancreatic cancer, breast cancer, lung cancer, esophageal cancer, gastric cancer, liver cancer, colorectal cancer, etc.

ZHANG YAN (CN)
WANG ZHENYU (CN)
ZHANG XUEJIAO (CN)
GUO JIANQIAO (CN)
HU JIMING (CN)
HUA XINXING (CN)
CHU WENHAO (CN)
AN HUI (CN)
QIN YANAN (CN)
WU HUIHUI (CN)
MU YONGZHAO (CN)
SHI HUIJING (CN)
GENG JIA (CN)

PCT/CN2020/101813

January 21, 2021

July 14, 2020

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CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN)

C07D403/12; A61K31/4155; A61K31/4184; A61K31/423; A61K31/4365; A61K31/4439; A61K31/454; A61K31/4985; A61K31/519; A61K31/5377; A61P31/14; A61P31/18; A61P33/02; A61P33/06; A61P35/00; C07D401/14; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D487/04; C07D495/04

WO2013083991A1	2013-06-13
WO2010026365A1	2010-03-11

US20180370974A1	2018-12-27
US20180370974A1	2018-12-27
CN102209717A	2011-10-05
CN107635970A	2018-01-26
CN101077866A	2007-11-28

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