Title:
COMPOUND AS PPAR AGONIST AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/141229
Kind Code:
A1
Abstract:
The present invention involves compounds as PPAR agonists and applications thereof. The compounds involved are novel peroxisome proliferator-activated receptor (PPAR) γ receptor agonists and can inhibit the production of mitochondrial reactive oxygen species. Most of the compounds can cross the blood-brain barrier. Also provided are pharmaceutical uses of the compounds.
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Inventors:
ZHANG MORGAN (CN)
GAO ZHICHAO (CN)
HUANG XIMING (CN)
LIU HUI (CN)
HU MIN (CN)
JIANG YAN (CN)
GAO ZHICHAO (CN)
HUANG XIMING (CN)
LIU HUI (CN)
HU MIN (CN)
JIANG YAN (CN)
Application Number:
PCT/CN2019/072302
Publication Date:
July 25, 2019
Filing Date:
January 18, 2019
Export Citation:
Assignee:
SHANGHAI ELIXIRIA BIOTECH CO LTD (CN)
USA ELIXIRIA BIOTECH INC (US)
USA ELIXIRIA BIOTECH INC (US)
International Classes:
A61K31/352; C07D215/227; A61K31/4704; A61K31/4741; A61K31/538; A61K31/553; A61P25/28; C07D209/88; C07D267/14; C07D311/76; C07D333/76
Domestic Patent References:
| WO1997023214A1 | 1997-07-03 |
Foreign References:
| CN108250058A | 2018-07-06 | |||
| US20140275060A1 | 2014-09-18 |
Other References:
CLARINA I. ET AL.: "Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 1, 13 November 2010 (2010-11-13) - 1 January 2011 (2011-01-01), pages 261 - 274, XP027577761
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
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