Title:
COMPOUND AS SHP2 INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/088945
Kind Code:
A1
Abstract:
The present invention falls within the field of medical chemistry and relates to a class of compounds as SHP2 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (I), or an isomer, a pharmaceutically acceptable salt, a solvate, a crystal or a prodrug thereof, a preparation method therefor, a pharmaceutical composition comprising the compounds, and the use of the compounds or the composition for treating a disease mediated by SHP2.
Inventors:
ZHAO LIWEN (CN)
WANG XIAOWEI (CN)
QUAN XU (CN)
YANG ZHISHUAI (CN)
WANG YAZHOU (CN)
XU TAO (CN)
WANG MINGXIAO (CN)
LIANG CHENG (CN)
GUO JING (CN)
TANG ZHICHAO (CN)
WANG CHUNMENG (CN)
LUO HAIZHOU (CN)
LI XUE (CN)
XU ZHENG (CN)
SUN TIANWEN (CN)
WANG XIAOWEI (CN)
QUAN XU (CN)
YANG ZHISHUAI (CN)
WANG YAZHOU (CN)
XU TAO (CN)
WANG MINGXIAO (CN)
LIANG CHENG (CN)
GUO JING (CN)
TANG ZHICHAO (CN)
WANG CHUNMENG (CN)
LUO HAIZHOU (CN)
LI XUE (CN)
XU ZHENG (CN)
SUN TIANWEN (CN)
Application Number:
PCT/CN2020/126916
Publication Date:
May 14, 2021
Filing Date:
November 06, 2020
Export Citation:
Assignee:
NANJING SANHOME PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/438; A61K31/496; A61K31/506; A61K31/519; A61P35/00; C07D471/20; C07D487/04; C07D491/113; C07D513/10; C07D519/00
Domestic Patent References:
| WO2019183367A1 | 2019-09-26 | |||
| WO2020072656A1 | 2020-04-09 | |||
| WO2020063760A1 | 2020-04-02 | |||
| WO2018172984A1 | 2018-09-27 |
Foreign References:
| CN111704611A | 2020-09-25 |
Other References:
See also references of EP 4056563A4
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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