Title:
COMPOUND CAPABLE OF BINDING S1P RECEPTOR AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO2005020882
Kind Code:
A3
Abstract:
A compound capable of binding S1P receptors (especially EDG-6, preferably EDG-1 and EDG-6). For example, a compound of the general formula (I), its salt or solvate, or a prodrug thereof is capable of binding S1P receptors (especially EDG-6, preferably EDG-1 and EDG-6) and is thus useful in the prevention and/or treatment of immunological reaction to transplant, graft versus host disease, autoimmune disease, allergosis, etc. (I) (wherein the ring A is a cyclic group; the ring B is an optionally substituted cyclic group; X is a spacer with a main chain of 1 to 8 atoms, etc.; Y is a spacer with a main chain of 1 to 10 atoms, etc.; and n is 0 or 1 provided that when n is 0, m is 1 and R<1> is a hydrogen atom or a substituent and that when n is 1, m is 0 or an integer of 1 to 7 and R<1> is a substituent, in which when m is 2 or greater, R<1>s may be identical with or different from each other).
Inventors:
NAKADE SHINJI (JP)
MIZUNO HIROTAKA (JP)
ONO TAKEJI (JP)
MINAMI MASASHI (JP)
SAGA HIROSHI (JP)
HAGIYA HIROSHI (JP)
KOMIYA TAKAKI (JP)
HABASHITA HIROMU (JP)
KURATA HARUTO (JP)
OHTSUKI KAZUHIRO (JP)
KUSUMI KENSUKE (JP)
MIZUNO HIROTAKA (JP)
ONO TAKEJI (JP)
MINAMI MASASHI (JP)
SAGA HIROSHI (JP)
HAGIYA HIROSHI (JP)
KOMIYA TAKAKI (JP)
HABASHITA HIROMU (JP)
KURATA HARUTO (JP)
OHTSUKI KAZUHIRO (JP)
KUSUMI KENSUKE (JP)
Application Number:
PCT/JP2004/012768
Publication Date:
April 21, 2005
Filing Date:
August 27, 2004
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
NAKADE SHINJI (JP)
MIZUNO HIROTAKA (JP)
ONO TAKEJI (JP)
MINAMI MASASHI (JP)
SAGA HIROSHI (JP)
HAGIYA HIROSHI (JP)
KOMIYA TAKAKI (JP)
HABASHITA HIROMU (JP)
KURATA HARUTO (JP)
OHTSUKI KAZUHIRO (JP)
KUSUMI KENSUKE (JP)
NAKADE SHINJI (JP)
MIZUNO HIROTAKA (JP)
ONO TAKEJI (JP)
MINAMI MASASHI (JP)
SAGA HIROSHI (JP)
HAGIYA HIROSHI (JP)
KOMIYA TAKAKI (JP)
HABASHITA HIROMU (JP)
KURATA HARUTO (JP)
OHTSUKI KAZUHIRO (JP)
KUSUMI KENSUKE (JP)
International Classes:
A61K31/11; A61K31/135; A61K31/197; A61K31/198; A61K31/222; A61K31/27; A61K31/277; A61K31/397; A61K31/472; A61K45/00; A61P37/06; A61P37/08; A61P43/00; C07C229/14; C07C229/22; C07C229/36; C07C233/47; C07C255/16; C07C255/41; C07C271/22; C07D205/04; C07D211/04; C07D217/04; C07D405/06; A61K; (IPC1-7): C07C229/14; C07C229/22; C07C229/36; C07C233/47; C07C255/16; C07C255/41; C07C271/22; C07D205/04; C07D211/04; C07D217/04; C07D405/06; A61K31/11; A61K31/135; A61K31/197; A61K31/198; A61K31/222; A61K31/27; A61K31/277; A61K31/397; A61K31/472; A61K45/00; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| WO2003061567A2 | 2003-07-31 | |||
| WO2003062248A2 | 2003-07-31 | |||
| WO2003062252A1 | 2003-07-31 | |||
| WO2002092068A1 | 2002-11-21 | |||
| WO2002018377A1 | 2002-03-07 | |||
| WO1996013497A1 | 1996-05-09 |
Other References:
See also references of EP 1661881A4
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