Title:
COMPOUND CAPABLE OF INHIBITING AND DEGRADING ANDROGEN RECEPTORS, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/007903
Kind Code:
A1
Abstract:
A compound as shown in general formula B-L-K (I) or stereoisomers, deuterated compounds, solvates, prodrugs, metabolites, pharmaceutically acceptable salts or co-crystals thereof, and intermediates thereof and uses thereof for AR-related diseases such as prostate cancer.
Inventors:
ZHANG CHEN (CN)
LIAO YUTING (CN)
ZHU GUOZHI (CN)
YE FEI (CN)
CHENG XINFAN (CN)
CHEN XIAOGANG (CN)
TANG PINGMING (CN)
LI YAO (CN)
NI JIA (CN)
YAN PANGKE (CN)
LIAO YUTING (CN)
ZHU GUOZHI (CN)
YE FEI (CN)
CHENG XINFAN (CN)
CHEN XIAOGANG (CN)
TANG PINGMING (CN)
LI YAO (CN)
NI JIA (CN)
YAN PANGKE (CN)
Application Number:
PCT/CN2021/105275
Publication Date:
January 13, 2022
Filing Date:
July 08, 2021
Export Citation:
Assignee:
SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/444; C07D401/14; A61K31/496; A61K31/517; A61P35/00; C07D417/14; C07D471/04; C07D471/08; C07D471/10
Domestic Patent References:
| WO1998022432A1 | 1998-05-28 | |||
| WO2019199816A1 | 2019-10-17 | |||
| WO2017197056A1 | 2017-11-16 | |||
| WO2020063407A1 | 2020-04-02 |
Foreign References:
| CN111051298A | 2020-04-21 | |||
| CN110963957A | 2020-04-07 | |||
| CN108601764A | 2018-09-28 | |||
| CN110612294A | 2019-12-24 |
Other References:
DATABASE REGISTRY 15 April 2011 (2011-04-15), ANONYMOUS : "1-Piperazineacetamide, N-phenyl-4-(2-tricyclo[3.3.1.13,7]dec-1-ylacetyl)- (CA INDEX NAME)", XP055886190, retrieved from STN Database accession no. 1280499-56-0
DATABASE REGISTRY 20 May 2011 (2011-05-20), ANONYMOUS : " Tricyclo[3.3.1.13,7]decane-1-acetic acid, 3-hydroxy-, [3-[2-[(2-methoxyphenyl)amino]-2-oxoethyl]-1,2,4-oxadiazol-5-yl]methyl ester (CA INDEX NAME)", XP055886189, retrieved from STN Database accession no. 1297716-76-7
S. R. SANDLER ET AL.: "Organic Functional Group Preparations", 1983, JOHN WILEY & SONS, INC.
H. O. HOUSE: "Modern Synthetic Reactions", 1972, W. A. BENJAMIN, INC
T. L. GILCHRIST: "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", 1992, WILEY-INTERSCIENCE
FUHRHOP, J.PENZLIN G.: "Organic Synthesis: Concepts, Methods, Starting Materials", 1994, JOHN WILEY & SONS
HOFFMAN, R.V.: "Organic Chemistry, An Intermediate Text", 1996, OXFORD UNIVERSITY PRESS
LAROCK, R. C.: "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia", 1999, JOHN WILEY & SONS
SOLOMONS, T. W. G: "Modern Carbonyl Chemistry", 2000, JOHN WILEY & SONS
STOWELL, J.C.: "Intermediate Organic Chemistry", 1993, WILEY-INTERSCIENCE
"Organic Reactions", vol. 55, 1942, JOHN WILEY & SONS
P. H. STAHLC. G. WERMUTH: "Handbook of Pharmaceutical Salts", vol. 73, 2002, VERLAG HELVETICA CHIMICA ACTA
DATABASE REGISTRY 20 May 2011 (2011-05-20), ANONYMOUS : " Tricyclo[3.3.1.13,7]decane-1-acetic acid, 3-hydroxy-, [3-[2-[(2-methoxyphenyl)amino]-2-oxoethyl]-1,2,4-oxadiazol-5-yl]methyl ester (CA INDEX NAME)", XP055886189, retrieved from STN Database accession no. 1297716-76-7
S. R. SANDLER ET AL.: "Organic Functional Group Preparations", 1983, JOHN WILEY & SONS, INC.
H. O. HOUSE: "Modern Synthetic Reactions", 1972, W. A. BENJAMIN, INC
T. L. GILCHRIST: "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", 1992, WILEY-INTERSCIENCE
FUHRHOP, J.PENZLIN G.: "Organic Synthesis: Concepts, Methods, Starting Materials", 1994, JOHN WILEY & SONS
HOFFMAN, R.V.: "Organic Chemistry, An Intermediate Text", 1996, OXFORD UNIVERSITY PRESS
LAROCK, R. C.: "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia", 1999, JOHN WILEY & SONS
SOLOMONS, T. W. G: "Modern Carbonyl Chemistry", 2000, JOHN WILEY & SONS
STOWELL, J.C.: "Intermediate Organic Chemistry", 1993, WILEY-INTERSCIENCE
"Organic Reactions", vol. 55, 1942, JOHN WILEY & SONS
P. H. STAHLC. G. WERMUTH: "Handbook of Pharmaceutical Salts", vol. 73, 2002, VERLAG HELVETICA CHIMICA ACTA
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
Download PDF: