Title:
COMPOUND AND COMPOSITION FOR DETECTING PHOSGENE AND DIETHYL CHLOROPHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2017/146400
Kind Code:
A1
Abstract:
The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.
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Inventors:
YOON JUYOUNG (KR)
ZHOU XIN (KR)
HU YING (KR)
CHEN LIYAN (KR)
ZHOU XIN (KR)
HU YING (KR)
CHEN LIYAN (KR)
Application Number:
PCT/KR2017/001389
Publication Date:
August 31, 2017
Filing Date:
February 08, 2017
Export Citation:
Assignee:
EWHA UNIV - IND COLLABORATION FOUND (KR)
International Classes:
C07D311/82; C07D209/08; C07D221/14; C07D271/12; G01N21/64; G01N33/00
Other References:
SUN, Y.-Q. ET AL.: "A mitochondria-targetable fluorescent probe for dual-channel NO imaging assisted by intracellular cysteine and glutathione", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, 2014, pages 12520 - 12523, XP055410532
KUMAR, V. ET AL.: "A reaction based turn-on type fluorogenic and chromogenic probe for the detection of trace amount of nitrite in water", TALANTA, vol. 99, 2012, pages 610 - 615, XP028936770
LIN, C.-Y. ET AL.: "A new selective colorimetric and fluorescent chemodosimeter for HS04- based on hydrolysis of Schiff base", MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol. 115, 2013, pages 552 - 558, XP055410533
WANG, X. ET AL.: "Screening and investigation of a cyanine fluorescent probe for simultaneous sensing of glutathione and cysteine under single excitation", CHEMICAL COMMUNICATIONS, vol. 50, 2014, pages 15439 - 15442, XP055410534
GUPTA, N. ET AL.: "An approach for the selective detection of nitric oxide in biological systems: An in vitro and in vivo perspective", CHEMISTRY - AN ASIAN JOURNAL, vol. 11, no. 7, 5 April 2016 (2016-04-05), pages 1020 - 1027, XP055410535
ZHOU,X. ET AL.: "A fluorescent sensor for dual-channel discrimination between phosgene and a nerve-gas mimic", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 55, 3 March 2016 (2016-03-03), pages 4729 - 4733, XP055410536
CHEN, L. ET AL.: "A fluorescent sensor for dual channel discrimination between phosgene and a nerve gas mimic", THE INTERNATIONAL SYMPOSIUM ON MACROCYCLIC AND SUPRAMOLECULAR CHEMISTRY, 10 July 2016 (2016-07-10)
YOON, J.: "Fluorescent probes for hypochlorous acid and phosgene", 5TH INTERNATIONAL CONFERENCE ON MOLECULAR SENSORS AND MOLECULAR LOGIC GATES IN THE CHANCELLOR'S BUILDING AT THE UNIVERSITY OF BATH, 24 July 2016 (2016-07-24)
HU , Y. ET AL.: "Effective strategy for colorimetric and fluorescence sensing of phosgene based on small organic dyes and nanofiber platforms", ACS APPLIED MATERIALS & INTERFACES, vol. 8, no. 34, 8 August 2016 (2016-08-08), pages 22246 - 22252, XP055410541
HU , Y. ET AL.: "Small organic dyes and nanofiber platforms based effective strategy for colorimetric and fluorescence sensing of phosgene", THE 118TH GENERAL MEETING OF THE KOREAN CHEMICAL SOCIETY , KOREA BUSAN, 12 October 2016 (2016-10-12)
KUMAR, V. ET AL.: "A reaction based turn-on type fluorogenic and chromogenic probe for the detection of trace amount of nitrite in water", TALANTA, vol. 99, 2012, pages 610 - 615, XP028936770
LIN, C.-Y. ET AL.: "A new selective colorimetric and fluorescent chemodosimeter for HS04- based on hydrolysis of Schiff base", MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol. 115, 2013, pages 552 - 558, XP055410533
WANG, X. ET AL.: "Screening and investigation of a cyanine fluorescent probe for simultaneous sensing of glutathione and cysteine under single excitation", CHEMICAL COMMUNICATIONS, vol. 50, 2014, pages 15439 - 15442, XP055410534
GUPTA, N. ET AL.: "An approach for the selective detection of nitric oxide in biological systems: An in vitro and in vivo perspective", CHEMISTRY - AN ASIAN JOURNAL, vol. 11, no. 7, 5 April 2016 (2016-04-05), pages 1020 - 1027, XP055410535
ZHOU,X. ET AL.: "A fluorescent sensor for dual-channel discrimination between phosgene and a nerve-gas mimic", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 55, 3 March 2016 (2016-03-03), pages 4729 - 4733, XP055410536
CHEN, L. ET AL.: "A fluorescent sensor for dual channel discrimination between phosgene and a nerve gas mimic", THE INTERNATIONAL SYMPOSIUM ON MACROCYCLIC AND SUPRAMOLECULAR CHEMISTRY, 10 July 2016 (2016-07-10)
YOON, J.: "Fluorescent probes for hypochlorous acid and phosgene", 5TH INTERNATIONAL CONFERENCE ON MOLECULAR SENSORS AND MOLECULAR LOGIC GATES IN THE CHANCELLOR'S BUILDING AT THE UNIVERSITY OF BATH, 24 July 2016 (2016-07-24)
HU , Y. ET AL.: "Effective strategy for colorimetric and fluorescence sensing of phosgene based on small organic dyes and nanofiber platforms", ACS APPLIED MATERIALS & INTERFACES, vol. 8, no. 34, 8 August 2016 (2016-08-08), pages 22246 - 22252, XP055410541
HU , Y. ET AL.: "Small organic dyes and nanofiber platforms based effective strategy for colorimetric and fluorescence sensing of phosgene", THE 118TH GENERAL MEETING OF THE KOREAN CHEMICAL SOCIETY , KOREA BUSAN, 12 October 2016 (2016-10-12)
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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