Title:
COMPOUND FOR DEGRADATION OF BCL-2 FAMILY PROTEINS AND MEDICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/030453
Kind Code:
A1
Abstract:
A compound of general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt, or a co-crystal thereof, an intermediate thereof, and a use thereof in Bcl-2 family proteins-related diseases such as cancer. B-L-K (I)
Inventors:
ZHANG CHEN (CN)
LIAO YUTING (CN)
LU YONGHUA (CN)
ZHAO JUNBIN (CN)
ZOU SIJIA (CN)
YU YAN (CN)
TANG PINGMING (CN)
GAO QIU (CN)
CHENG XINFAN (CN)
YE FEI (CN)
LI YAO (CN)
NI JIA (CN)
YAN PANGKE (CN)
LIAO YUTING (CN)
LU YONGHUA (CN)
ZHAO JUNBIN (CN)
ZOU SIJIA (CN)
YU YAN (CN)
TANG PINGMING (CN)
GAO QIU (CN)
CHENG XINFAN (CN)
YE FEI (CN)
LI YAO (CN)
NI JIA (CN)
YAN PANGKE (CN)
Application Number:
PCT/CN2022/116529
Publication Date:
March 09, 2023
Filing Date:
September 01, 2022
Export Citation:
Assignee:
SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/5377; A61P35/00; C07K5/083
Domestic Patent References:
| WO2020163823A2 | 2020-08-13 | |||
| WO2017185023A1 | 2017-10-26 | |||
| WO2019144117A1 | 2019-07-25 | |||
| WO2017184995A1 | 2017-10-26 | |||
| WO2020163823A2 | 2020-08-13 | |||
| WO2017101851A1 | 2017-06-22 | |||
| WO2020041406A1 | 2020-02-27 | |||
| WO2020212530A1 | 2020-10-22 | |||
| WO2013185202A1 | 2013-12-19 | |||
| WO2021066873A1 | 2021-04-08 | |||
| WO2021262812A1 | 2021-12-30 |
Foreign References:
| CN105985321A | 2016-10-05 | |||
| CN114292270A | 2022-04-08 |
Other References:
NEGI ARVIND, VOISIN‐CHIRET ANNE SOPHIE: "Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐x L Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches", CHEMBIOCHEM, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 23, no. 12, 20 June 2022 (2022-06-20), Hoboken, USA, XP093041985, ISSN: 1439-4227, DOI: 10.1002/cbic.202100689
ZHANG XUAN; THUMMURI DINESH; LIU XINGUI; HU WANYI; ZHANG PEIYI; KHAN SAJID; YUAN YAXIA; ZHOU DAOHONG; ZHENG GUANGRONG: "Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 192, 27 February 2020 (2020-02-27), AMSTERDAM, NL , XP086102467, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112186
ZHANG XUAN; HE YONGHAN; ZHANG PEIYI; BUDAMAGUNTA VIVEKANANDA; LV DONGWEN; THUMMURI DINESH; YANG YANG; PEI JING; YUAN YAXIA; ZHOU D: "Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 199, 4 May 2020 (2020-05-04), AMSTERDAM, NL , XP086185914, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112397
HE YONGHAN, ZHANG XUAN, CHANG JIANHUI, KIM HA-NEUI, ZHANG PEIYI, WANG YINGYING, KHAN SAJID, LIU XINGUI, ZHANG XIN, LV DONGWEN, SON: "Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity", NATURE COMMUNICATIONS, vol. 11, no. 1, XP093041989, DOI: 10.1038/s41467-020-15838-0
S. R. SANDLER ET AL.: "Organic Functional Group Preparations", 1983, JOHN WILEY & SONS
H. O. HOUSE: "Modern Synthetic Reactions", 1972, W. A. BENJAMIN
T. L. GILCHRIST: "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", 1992, WILEY-INTERSCIENCE
FUHRHOP, JPENZLIN G: "Organic Synthesis: Concepts, Methods, Starting Materials", 1994, JOHN WILEY & SONS
HOFFMAN, R.V: "Organic Chemistry, An Intermediate Text", 1996, OXFORD UNIVERSITY PRESS
LAROCK, R. C: "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia", vol. 8, 1999, JOHN WILEY & SONS
SOLOMONS, T. W. G: "Modern Carbonyl Chemistry", 2000, JOHN WILEY & SONS
STOWELL, J.C.: "Intermediate Organic Chemistry", 1993, WILEY-INTERSCIENCE
"Organic Reactions", vol. 55, 1942, JOHN WILEY & SONS
NATURE COMMUNICATIONS, vol. 11, 2020, pages 1996
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 149, 2018, pages 79 - 89
ZHANG XUAN; THUMMURI DINESH; LIU XINGUI; HU WANYI; ZHANG PEIYI; KHAN SAJID; YUAN YAXIA; ZHOU DAOHONG; ZHENG GUANGRONG: "Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 192, 27 February 2020 (2020-02-27), AMSTERDAM, NL , XP086102467, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112186
ZHANG XUAN; HE YONGHAN; ZHANG PEIYI; BUDAMAGUNTA VIVEKANANDA; LV DONGWEN; THUMMURI DINESH; YANG YANG; PEI JING; YUAN YAXIA; ZHOU D: "Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 199, 4 May 2020 (2020-05-04), AMSTERDAM, NL , XP086185914, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112397
HE YONGHAN, ZHANG XUAN, CHANG JIANHUI, KIM HA-NEUI, ZHANG PEIYI, WANG YINGYING, KHAN SAJID, LIU XINGUI, ZHANG XIN, LV DONGWEN, SON: "Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity", NATURE COMMUNICATIONS, vol. 11, no. 1, XP093041989, DOI: 10.1038/s41467-020-15838-0
S. R. SANDLER ET AL.: "Organic Functional Group Preparations", 1983, JOHN WILEY & SONS
H. O. HOUSE: "Modern Synthetic Reactions", 1972, W. A. BENJAMIN
T. L. GILCHRIST: "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", 1992, WILEY-INTERSCIENCE
FUHRHOP, JPENZLIN G: "Organic Synthesis: Concepts, Methods, Starting Materials", 1994, JOHN WILEY & SONS
HOFFMAN, R.V: "Organic Chemistry, An Intermediate Text", 1996, OXFORD UNIVERSITY PRESS
LAROCK, R. C: "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia", vol. 8, 1999, JOHN WILEY & SONS
SOLOMONS, T. W. G: "Modern Carbonyl Chemistry", 2000, JOHN WILEY & SONS
STOWELL, J.C.: "Intermediate Organic Chemistry", 1993, WILEY-INTERSCIENCE
"Organic Reactions", vol. 55, 1942, JOHN WILEY & SONS
NATURE COMMUNICATIONS, vol. 11, 2020, pages 1996
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 149, 2018, pages 79 - 89
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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