COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES

Title:

COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES

Document Type and Number:

WIPO Patent Application WO/2014/007228

Kind Code:

A1

Abstract:

Provided is a somatostatin receptor subtype-2 agonist which can be administered orally and has low toxicity. A compound represented by general formula (I) [wherein all of symbols are as defined in the description], a salt of the compound, an N-oxide or solvate of the compound or the salt, or a prodrug of the compound, the salt or the N-oxide or solvate is a non-peptide-type low-molecular-weight compound having a potent agonistic activity on somatostatin receptor subtype-2 and therefore can be administered orally, and has low toxicity. Therefore, the compound, the salt, the N-oxide or solvate or the prodrug is useful for the prevention and/or treatment of somatostatin-related diseases such as acromegaly and bowel obstruction.

Inventors:

ISHIDA AKIHARU (JP)
MATSUSHITA TAKESHI (JP)
SEKIGUCHI TETSUYA (JP)
KOMAGATA TATSUYA (JP)
NISHIO TAKUYA (JP)

Application Number:

PCT/JP2013/068084

Publication Date:

January 09, 2014

Filing Date:

July 02, 2013

Export Citation:

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Assignee:

ONO PHARMACEUTICAL CO (JP)

International Classes:

C07D211/58; A61K31/4184; A61K31/4418; A61K31/4427; A61K31/451; A61K31/4545; A61K31/455; A61K31/4709; A61K31/48; A61K31/496; A61K31/4985; A61K31/517; A61K31/519; A61K38/00; A61P1/00; A61P5/06; A61P43/00; C07D213/75; C07D213/82; C07D235/18; C07D401/04; C07D401/12; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D471/10; C07D487/04

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Foreign References:

JP2013060370A

2013-04-04

Other References:

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See also references of EP 2871179A4
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Attorney, Agent or Firm:

SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)

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