Title:
COMPOUND HAVING ANTI-DRUG-RESISTANT BACTERIA ACTIVITY, PREPARATION FOR SAME, AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/096234
Kind Code:
A1
Abstract:
As represented by formula I, a glycopeptide antibiotic compound having anti-drug-resistant bacteria activity or a pharmaceutically acceptable salt of same, a pharmaceutical preparation of same, a preparation method for same, and applications thereof. The compound of formula I has enhanced inhibitory activity against drug-resistant strains, particularly methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE), and is applicable in preparing a medicament for treating or preventing various diseases induced by bacterial infection such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.
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Inventors:
SHAO CHANG (CN)
GE MEI (CN)
RUAN LINGAO (CN)
WEI WEI (CN)
XIA XING (CN)
RAO MIN (CN)
MENG QINGQIAN (CN)
LUO MINYU (CN)
GE MEI (CN)
RUAN LINGAO (CN)
WEI WEI (CN)
XIA XING (CN)
RAO MIN (CN)
MENG QINGQIAN (CN)
LUO MINYU (CN)
Application Number:
PCT/CN2018/115811
Publication Date:
May 23, 2019
Filing Date:
November 16, 2018
Export Citation:
Assignee:
SHANGHAI LAIYI CENTER FOR BIOPHARMACEUTICAL R&D CO LTD (CN)
ZHEJIANG MEDICINE CO LTD (CN)
ZHEJIANG MEDICINE CO LTD (CN)
International Classes:
C07K7/06; A61K38/08; A61K38/14; A61P31/04; C07K1/113; C07K9/00
Foreign References:
| CN107987131A | 2018-05-04 | |||
| CN102690332A | 2012-09-26 |
Other References:
SHAO, CHANG ET AL.: "Synthesis and Antibacterial Activity of N4-mono Alkyl Derivatives of Novel Glycopeptide LYV07ww01", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 22, 18 September 2011 (2011-09-18), pages 6732, XP028320727, ISSN: 0960-894X, DOI: doi:10.1016/j.bmcl.2011.09.045
Attorney, Agent or Firm:
SHANGHAI HUAGONG PATENT AGENCY (CN)
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