Title:
COMPOUND HAVING ANTIPARASITIC ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2022/239808
Kind Code:
A1
Abstract:
Provided are a compound and an antiparasitic agent that have an antiparasitic activity against zoonotic parasites consisting of protozoa and helminths and are useful for treating or preventing parasitic infections. This antiparasitic agent comprises a compound represented by general formula (I) or a salt thereof [in the formula: Ar1 represents an optionally substituted nitrogen-containing heteroaromatic ring group; X represents a hydroxyl group, an amino group or -NR1R2; Y represents a hydrogen atom, a C1-6 alkyl group, an aryl group or a halogen atom; A represents (1) a single bond or (2) an optionally substituted C1-3 alkylene group optionally containing an intervening oxygen or sulfur atom; and Ar2 represents an optionally substituted aryl group or an optionally substituted heteroaryl group].
Inventors:
TANAKA AKIKO (JP)
SEKIMATA KATSUHIKO (JP)
KITA KIYOSHI (JP)
INAOKA KEN DANIEL (JP)
NARA TAKESHI (JP)
SEKIMATA KATSUHIKO (JP)
KITA KIYOSHI (JP)
INAOKA KEN DANIEL (JP)
NARA TAKESHI (JP)
Application Number:
PCT/JP2022/019962
Publication Date:
November 17, 2022
Filing Date:
May 11, 2022
Export Citation:
Assignee:
RIKEN (JP)
UNIV NAGASAKI (JP)
IRYO SOSEI UNIV (JP)
UNIV NAGASAKI (JP)
IRYO SOSEI UNIV (JP)
International Classes:
A61K31/506; A01N43/54; A01P1/00; A01P5/00; A61P33/00; C07D401/04
Foreign References:
| US5250530A | 1993-10-05 | |||
| JP2003026675A | 2003-01-29 | |||
| JPS63264478A | 1988-11-01 | |||
| JPH03251581A | 1991-11-11 | |||
| JPH04257577A | 1992-09-11 | |||
| JP2016121072A | 2016-07-07 |
Other References:
NEIL R. NORCROSS, BEATRIZ BARAGAñA, CAROLINE WILSON, IRENE HALLYBURTON, MARIA OSUNA-CABELLO, SUZANNE NORVAL, JENNIFER RILEY, : "Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 13, 14 July 2016 (2016-07-14), US , pages 6101 - 6120, XP055620338, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00028
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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