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Title:
COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/154329
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt and a pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Inventors:
XIA, Lin (Rm. 208, Section 103 Building 6, No. 421, Newton Rd., China Pilot Free Trade Zone, Shanghai 3, 201203, CN)
GENG, Meiyu (555 Zuchongzhi Road, Zhangjiang Pudong, Shanghai 3, 201203, CN)
YE, Yan (Rm. 208, Section 103 Building 6, No. 421, Newton Rd., China Pilot Free Trade Zone, Shanghai 3, 201203, CN)
DING, Jian (555 Zuchongzhi Road, Zhangjiang Pudong, Shanghai 3, 201203, CN)
ZHANG, Qiong (Rm. 208, Section 103 Building 6, No. 421, Newton Rd., China Pilot Free Trade Zone, Shanghai 3, 201203, CN)
SHEN, Aijun (555 Zuchongzhi Road, Zhangjiang Pudong, Shanghai 3, 201203, CN)
HUANG, Ying (Rm. 208, Section 103 Building 6, No. 421, Newton Rd., China Pilot Free Trade Zone, Shanghai 3, 201203, CN)
LIU, Hongchun (555 Zuchongzhi Road, Zhangjiang Pudong, Shanghai 3, 201203, CN)
YANG, Haoran (Rm. 208, Section 103 Building 6, No. 421, Newton Rd., China Pilot Free Trade Zone, Shanghai 3, 201203, CN)
AI, Jing (555 Zuchongzhi Road, Zhangjiang Pudong, Shanghai 3, 201203, CN)
ZHANG, Minmin (555 Zuchongzhi Road, Zhangjiang Pudong, Shanghai 3, 201203, CN)
Application Number:
CN2019/074448
Publication Date:
August 15, 2019
Filing Date:
February 01, 2019
Export Citation:
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Assignee:
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (Rm. 208, Section 103 Building 6, No. 421, Newton Rd., China Pilot Free Trade Zone, Shanghai 3, 201203, CN)
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (555 Zuchongzhi Road, Zhangjiang Pudong, Shanghai 3, 201203, CN)
International Classes:
C07D401/04; A61K31/402; A61K31/4025; A61P21/00; C07D403/04; C07D403/14
Domestic Patent References:
WO2009042907A12009-04-02
Foreign References:
CN104245675A2014-12-24
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (7F New Era Building, 26 Pinganli Xidajie Xicheng District, Beijing 4, 100034, CN)
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