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Title:
COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/154329
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt and a pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Inventors:
XIA LIN (CN)
GENG MEIYU (CN)
YE YAN (CN)
DING JIAN (CN)
ZHANG QIONG (CN)
SHEN AIJUN (CN)
HUANG YING (CN)
LIU HONGCHUN (CN)
YANG HAORAN (CN)
AI JING (CN)
ZHANG MINMIN (CN)
Application Number:
PCT/CN2019/074448
Publication Date:
August 15, 2019
Filing Date:
February 01, 2019
Export Citation:
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Assignee:
SHANGHAI HAIHE PHARMACEUTICAL CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D401/04; A61K31/402; A61K31/4025; A61P21/00; C07D403/04; C07D403/14
Domestic Patent References:
WO2009042907A12009-04-02
Foreign References:
CN104245675A2014-12-24
Other References:
See also references of EP 3750885A4
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
E. L. ELIELS. H. WILENL. N. MANDER: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
ALLINGER N. L.ELIEL E. L.: "Topics in Stereochemistry", vol. 6, 1971, WILEY INTERSCIENCE
T. W. GREENEEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 2014, WILEY
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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