Title:
COMPOUND HAVING CLK AND DYRK INHIBITORY ACTIVITIES, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/103898
Kind Code:
A1
Abstract:
Provided is a novel compound having a macrocyclic structure. Specifically, provided are a compound having a macrocyclic structure of formula (I), or a pharmaceutically acceptable salt or a deuterated form thereof, and a method for preparing such compounds. This type of compounds has inhibitory effects on DYRK and/or CLK.
Inventors:
YANG ANLE (CN)
HE QUANHONG (CN)
WANG ZHI (CN)
ZHANG DEWEI (CN)
LI ZERUI (CN)
YU PAN (CN)
CHI ZHEXIN (CN)
YANG XUDONG (CN)
HU DONGJIE (CN)
XIAN JIALING (CN)
SHEN HUAN (CN)
MENG JIANG (CN)
TANG YUANQING (CN)
TANG JUN (CN)
HE QUANHONG (CN)
WANG ZHI (CN)
ZHANG DEWEI (CN)
LI ZERUI (CN)
YU PAN (CN)
CHI ZHEXIN (CN)
YANG XUDONG (CN)
HU DONGJIE (CN)
XIAN JIALING (CN)
SHEN HUAN (CN)
MENG JIANG (CN)
TANG YUANQING (CN)
TANG JUN (CN)
Application Number:
PCT/CN2022/136149
Publication Date:
June 15, 2023
Filing Date:
December 02, 2022
Export Citation:
Assignee:
SCINNOHUB PHARMACEUTICAL CO LTD (CN)
CHENGDU BRILLIANT PHARMACEUTICAL CO LTD (CN)
CHENGDU BRILLIANT PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/22; A61K31/529; A61P25/00; A61P29/00; A61P35/00; A61P37/00; C07D487/22; C07D513/22
Domestic Patent References:
| WO2020150552A2 | 2020-07-23 | |||
| WO2020006115A1 | 2020-01-02 | |||
| WO2021091982A1 | 2021-05-14 |
Other References:
IWAI KENICHI; YAGUCHI MASAHIRO; NISHIMURA KAZUHO; YAMAMOTO YUKIKO; TAMURA TOSHIYA; NAKATA DAISUKE; DAIRIKI RYO; KAWAKITA YOICHI; M: "Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.", EMBO MOLECULAR MEDICINE (ONLINE), WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 10, no. 6, 31 May 2018 (2018-05-31), DE , pages 1 - 15, XP009535850, ISSN: 1757-4684, DOI: 10.15252/emmm.201708289
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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