Title:
COMPOUND HAVING DETRUSOR MUSCLE-CONTRACTING ACTIVITY AND URETHRAL SPHINCTER MUSCLE-RELAXING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2010/143661
Kind Code:
A1
Abstract:
Disclosed is a compound represented by general formula (I) (wherein all of the symbols are as defined in the description), a salt or solvate of the compound, or a prodrug of the compound or the salt or solvate, a mixture of the compound with a diastereomer thereof at an arbitral ratio, or a cyclodextrin inclusion compound of the compound, which has a detrusor muscle-contracting activity and a urethral sphincter muscle-relaxing activity, and therefore can ameliorate bladder contraction disorders and/or urethral relaxation disorders, and is effective on, for example, underactive bladder. The compound has no risk of adverse side effects on a urinary system, a circulatory system and a digestive system, and has excellent pharmacokinetics including oral absorbability. As mentioned above, the compound is useful as a superior prophylactic, therapeutic and/or condition-ameliorating agent for underactive bladder.
Inventors:
OHMOTO KAZUYUKI (JP)
KINOSHITA AKIHIRO (JP)
MATSUYA HIDEKAZU (JP)
OKADA HIROKI (JP)
KINOSHITA AKIHIRO (JP)
MATSUYA HIDEKAZU (JP)
OKADA HIROKI (JP)
Application Number:
PCT/JP2010/059771
Publication Date:
December 16, 2010
Filing Date:
June 09, 2010
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
OHMOTO KAZUYUKI (JP)
KINOSHITA AKIHIRO (JP)
MATSUYA HIDEKAZU (JP)
OKADA HIROKI (JP)
OHMOTO KAZUYUKI (JP)
KINOSHITA AKIHIRO (JP)
MATSUYA HIDEKAZU (JP)
OKADA HIROKI (JP)
International Classes:
C07D277/20; A61K31/426; A61K45/00; A61P13/02; A61P13/10; A61P43/00; C07D277/56
Domestic Patent References:
| WO2006129788A1 | 2006-12-07 | |||
| WO2005053707A1 | 2005-06-16 | |||
| WO2006016689A1 | 2006-02-16 | |||
| WO2009148163A1 | 2009-12-10 | |||
| WO2005053707A1 | 2005-06-16 | |||
| WO2006129788A1 | 2006-12-07 |
Foreign References:
| JPS503362B1 | 1975-02-04 | |||
| JPS5231404B1 | 1977-08-15 | |||
| JPS6152146B2 | 1986-11-12 |
Other References:
NURSING STANDARD, vol. 19, no. 35, 11 May 2005 (2005-05-11), pages 57 - 64
PRACTICE OF INTRACTABLE AND CHRONIC DYSURIA, UROLOGY VIEW, vol. 2, no. 5, 2004, pages 57 - 65
"The standardization of terminology in functions of lower urinary tract: report from the International Continence Society (ICS) Standardization Steering Committee", JOURNAL OF THE JAPAN NEUROGENIC BLADDER SOCIETY, vol. 14, no. 2, 20 December 2003 (2003-12-20), pages 104 - 118
"Diagnosis and Therapy of Neurogenic Bladder", 1990, IGAKU-SHOIN LTD., pages: 105 - 106,139
"Molecular Design", vol. 7, 1990, HIROKAWASHOTEN, article "Development of Medicines", pages: 163 - 198
SYNLETT, vol. 1, 2002, pages 239 - 242
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, WILEY
See also references of EP 2441760A4
PRACTICE OF INTRACTABLE AND CHRONIC DYSURIA, UROLOGY VIEW, vol. 2, no. 5, 2004, pages 57 - 65
"The standardization of terminology in functions of lower urinary tract: report from the International Continence Society (ICS) Standardization Steering Committee", JOURNAL OF THE JAPAN NEUROGENIC BLADDER SOCIETY, vol. 14, no. 2, 20 December 2003 (2003-12-20), pages 104 - 118
"Diagnosis and Therapy of Neurogenic Bladder", 1990, IGAKU-SHOIN LTD., pages: 105 - 106,139
"Molecular Design", vol. 7, 1990, HIROKAWASHOTEN, article "Development of Medicines", pages: 163 - 198
SYNLETT, vol. 1, 2002, pages 239 - 242
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, WILEY
See also references of EP 2441760A4
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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