Title:
COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION
Document Type and Number:
WIPO Patent Application WO2001040187
Kind Code:
A3
Abstract:
Neuroprotective agents are disclosed having structure: (I) and stereoisomers and pharmaceutically acceptable salts thereof, wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl; R2 is -OR2a or -NR2bR2c; R3 is hydrogen, keto, -C(=O)OR3a or -C(=O)NR3bR3c; R4 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, -C(=O)R4a, -C(=O)OR4b, -C(=O)NR4cR4d, -OC(=O)NR4cR4d or -SO2R4c or wherein R3 and R4 taken together form a heterocyclic ring or substituted heterocyclic ring; and R5 is hydrogen, alkyl or substituted alkyl. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.
Inventors:
BHAGWAT SHRIPAD
PALANKI MOORTHY
ERDMAN PAUL
DOUBLEDAY MARY
SATO HIROSHI
PALANKI MOORTHY
ERDMAN PAUL
DOUBLEDAY MARY
SATO HIROSHI
Application Number:
PCT/JP2000/008090
Publication Date:
July 11, 2002
Filing Date:
November 16, 2000
Export Citation:
Assignee:
NIPPON KAYAKU KK (JP)
International Classes:
C07D213/55; A61K31/4406; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/498; A61K31/5377; A61P9/00; A61P9/10; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C07C323/59; C07D213/50; C07D213/56; C07D213/81; C07D239/26; C07D277/24; C07D277/64; C07D401/12; C07D401/14; C07D405/12; C07D407/12; C07D409/12; C07D413/12; C07D417/12; C07D495/04; (IPC1-7): C07D213/55; A61K31/44; A61P25/00; C07D213/56; C07D417/12
Domestic Patent References:
| WO1999005091A1 | 1999-02-04 |
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