Title:
COMPOUND HAVING INHIBITORY ACTIVITY ON HISTONE DEACETYLASE, AND PHARMACEUTICAL COMPRISING THE COMPOUND AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2008/029565
Kind Code:
A1
Abstract:
Disclosed is a novel compound having an inhibitory activity on histone deacetylase, which
comprises a cyclic tetrapeptide derivative represented by the general formula
(1). Also disclosed is a pharmaceutical comprising the compound as an active
ingredient. (1) wherein the cyclic tetrapeptide moiety is a known structure; R1
and R2 independently represent an alkylene group which may have a branch
having 1 to 6 carbon atoms; X represents a group selected from –CO-, -O-,
-S- and –SO-; and Y represents a hydrogen, a halogen, a phenyl group (including
a substituted form), a pyridyl group (including a substituted form), an alkyl
group having 1 to 6 carbon atoms (including a halogen-substituted form, ditto
with the groups described below), an alkyloxy group having 1 to 6 carbon atoms,
an alkylcarbonyl group having 1 to 6 carbon atoms, an alkyloxycarbonyl group
having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, an alkylthiocarbonyl
group having 1 to 6 carbon atoms or a mono- or di-alkylamino group having 1 to 6 carbon
atoms, provided that, when Y represents a phenyl group (including a substituted
form) or a pyridyl group (including a substituted form), Y may have a cyclic structure
bound to R2.
Inventors:
NISHINO, Norikazu (Graduate School of Life Science and Systems Engineering 2-4, Hibikino, Wakamatsu-ku, Kitakyushu-sh, Fukuoka 96, 8080196, JP)
西野 憲和 (〒96 福岡県北九州市若松区ひびきの２番４号 九州工業大学大学院生命体工学研究科内 Fukuoka, 8080196, JP)
YOSHIDA, Minoru (2-1 Hirosawa, Wako-sh, Saitama 98, 3510198, JP)
西野 憲和 (〒96 福岡県北九州市若松区ひびきの２番４号 九州工業大学大学院生命体工学研究科内 Fukuoka, 8080196, JP)
YOSHIDA, Minoru (2-1 Hirosawa, Wako-sh, Saitama 98, 3510198, JP)
Application Number:
JP2007/064873
Publication Date:
March 13, 2008
Filing Date:
July 30, 2007
Export Citation:
Assignee:
Kyushu Institute of Technology (1-1 Sensui-cho, Tobata-ku Kitakyushu-sh, Fukuoka 50, 8048550, JP)
国立大学法人九州工業大学 (〒50 福岡県北九州市戸畑区仙水町１番１号 Fukuoka, 8048550, JP)
RIKEN (2-1 Hirosawa, Wako-shi Saitama, 98, 3510198, JP)
独立行政法人理化学研究所 (〒98 埼玉県和光市広沢２番１号 Saitama, 3510198, JP)
NISHINO, Norikazu (Graduate School of Life Science and Systems Engineering 2-4, Hibikino, Wakamatsu-ku, Kitakyushu-sh, Fukuoka 96, 8080196, JP)
国立大学法人九州工業大学 (〒50 福岡県北九州市戸畑区仙水町１番１号 Fukuoka, 8048550, JP)
RIKEN (2-1 Hirosawa, Wako-shi Saitama, 98, 3510198, JP)
独立行政法人理化学研究所 (〒98 埼玉県和光市広沢２番１号 Saitama, 3510198, JP)
NISHINO, Norikazu (Graduate School of Life Science and Systems Engineering 2-4, Hibikino, Wakamatsu-ku, Kitakyushu-sh, Fukuoka 96, 8080196, JP)
International Classes:
C07K5/12; A61K38/00; A61P3/10; A61P29/00; A61P35/00; A61P43/00; C12N9/99; C07K5/00; A61K38/00; A61P3/00; A61P29/00; A61P35/00; A61P43/00; C12N9/99
Attorney, Agent or Firm:
NOGUCHI, Yasuhiro (NOGUCHI PATENT FIRM, Urban Toranomon Bldg. 16-4,Toranomon 1-chome, Minato-k, Tokyo 01, 1050001, JP)
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