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Title:
COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2017/036405
Kind Code:
A1
Abstract:
A compound having a chemical structure of formula I, wherein n is 0 or 1, X is N or C-R1, R1 is H or Cl, R2 and R3 are independently H, a halogen or an alkyl group, Ar is a substituted or unsubstituted phenylene or naphthylene group, with the substituted or unsubstituted phenylene group being A or B, and the naphthylene group being C, R4 is H, a halogen or an alkyl group, R5 is H, a halogen, an alkyl group, an alkoxyl group or a hydroxyl group, R6 is H or a hydroxyl group, and R7 is a substituted or unsubstituted aryl group. The compound has SHP-1 agonist activity, and can be used to treat cancer.

Inventors:
CHEN, Kuenfeng (No.7, Jhongshan S. Rd. Jhongjheng Dist, Taipei City Taiwan, 10002, CN)
SHIAU, Chungwai (No.155, Sec.2 Linong Street, Beitou Dist, Taipei City Taiwan 112, 112, CN)
Application Number:
CN2016/097663
Publication Date:
March 09, 2017
Filing Date:
August 31, 2016
Export Citation:
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Assignee:
CHEN, Kuenfeng (No.7, Jhongshan S. Rd. Jhongjheng Dist, Taipei City Taiwan, 10002, CN)
SHIAU, Chungwai (No.155, Sec.2 Linong Street, Beitou Dist, Taipei City Taiwan 112, 112, CN)
International Classes:
C07C275/36; A61K31/155; C07C235/82; C07C237/16; C07C237/24; C07C317/26
Domestic Patent References:
2013-02-07
2015-04-09
2004-09-16
2003-08-21
2007-10-25
2013-04-25
Foreign References:
US20140148482A12014-05-29
US3906033A1975-09-16
US2867658A1959-01-06
GB1326481A1973-08-15
US2745874A1956-05-15
BE617117A
EP0512211A21992-11-11
Other References:
TAI, W.T. ET AL.: "SC-60, a Dimer-Based Sorafenib Derivative, Shows a Better Anti-Hepatocellular Carcinoma Effect than Sorafenib in a Preclinical Hepatocellular Carcinoma Model", MOL. CANCER THER., vol. 13, no. 1, 31 January 2014 (2014-01-31), pages 27 - 36, XP055367644, ISSN: 1535-7163
DATABASE REGISTRY 30 July 2015 (2015-07-30), retrieved from STN Database accession no. 1800600-09-02
Attorney, Agent or Firm:
DRAGON INTELLECTUAL PROPERTY LAW FIRM (10F Bldg.2, Maples International CenterNo.32 Xizhimen North Street, Haidian District, Beijing 2, 100082, CN)
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